PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17082483-3 2007 METHODS AND RESULTS: In cultured rat aortic smooth muscle cells, treatment with atorvastatin significantly increased nNOS expression, associated with activation of Akt and NF-kappaB. Atorvastatin 80-92 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 172-181 17082483-5 2007 Inhibition of NF-kappaB by dominant-negative IkappaB also attenuated atorvastatin-induced nNOS expression and NF-kappaB activation, but not Akt activation. Atorvastatin 69-81 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 14-23 17082483-5 2007 Inhibition of NF-kappaB by dominant-negative IkappaB also attenuated atorvastatin-induced nNOS expression and NF-kappaB activation, but not Akt activation. Atorvastatin 69-81 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 110-119 17082483-9 2007 CONCLUSIONS: These results indicate that atorvastatin upregulates vascular nNOS through Akt/NF-kappaB pathway, demonstrating a novel nNOS-mediated vascular effect of the statin. Atorvastatin 41-53 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 92-101