PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17009102-5 2007 RESULTS: The reverse-charge mutants R282D-hPepT1 and D341R-hPepT1 showed significantly reduced gly-sar uptake, but the double mutant (R282D/D341R-hPepT1) has functionality comparable to that of wild-type hPepT1. Glycine 95-98 solute carrier family 15 member 1 Homo sapiens 42-48 17009102-5 2007 RESULTS: The reverse-charge mutants R282D-hPepT1 and D341R-hPepT1 showed significantly reduced gly-sar uptake, but the double mutant (R282D/D341R-hPepT1) has functionality comparable to that of wild-type hPepT1. Glycine 95-98 solute carrier family 15 member 1 Homo sapiens 59-65 17009102-5 2007 RESULTS: The reverse-charge mutants R282D-hPepT1 and D341R-hPepT1 showed significantly reduced gly-sar uptake, but the double mutant (R282D/D341R-hPepT1) has functionality comparable to that of wild-type hPepT1. Glycine 95-98 solute carrier family 15 member 1 Homo sapiens 59-65 17009102-5 2007 RESULTS: The reverse-charge mutants R282D-hPepT1 and D341R-hPepT1 showed significantly reduced gly-sar uptake, but the double mutant (R282D/D341R-hPepT1) has functionality comparable to that of wild-type hPepT1. Glycine 95-98 solute carrier family 15 member 1 Homo sapiens 59-65 17009102-6 2007 Gly-sar uptake by R282C-hPepT1 is reduced, but pre-incubation with 1 mM MTSET, a positively charged cysteine-modifying reagent, restored function to wild-type levels. Glycine 0-3 solute carrier family 15 member 1 Homo sapiens 24-30 17009102-7 2007 Similarly, pre-incubation of D341C-hPepT1 with 10 mM MTSES, a negatively charged cysteine-modifying reagent, increased gly-sar uptake compared to unmodified D341C-hPepT1. Glycine 119-122 solute carrier family 15 member 1 Homo sapiens 35-41 17009102-8 2007 In contrast, MTSET modification of D341C-hPepT1 (giving a positive charge at position 341) resulted in significant reduction in gly-sar uptake, compared to D341C-hPepT1. Glycine 128-131 solute carrier family 15 member 1 Homo sapiens 41-47