PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16973122-2	2006	We here demonstrate that the anti-apoptotic kinase Akt is activated in HepG2 human hepatoma cells exposed to copper or zinc ions.	Copper	109-115	AKT serine/threonine kinase 1	Homo sapiens	51-54	
16973122-3	2006	Cu2+- and Zn2+-induced phosphorylation of Akt was blocked by phosphoinositide 3-kinase (PI3K) inhibitors, wortmannin and LY294002.	cupric ion	0-4	AKT serine/threonine kinase 1	Homo sapiens	42-45	
16973122-3	2006	Cu2+- and Zn2+-induced phosphorylation of Akt was blocked by phosphoinositide 3-kinase (PI3K) inhibitors, wortmannin and LY294002.	Zinc	10-14	AKT serine/threonine kinase 1	Homo sapiens	42-45	
16973122-3	2006	Cu2+- and Zn2+-induced phosphorylation of Akt was blocked by phosphoinositide 3-kinase (PI3K) inhibitors, wortmannin and LY294002.	Wortmannin	106-116	AKT serine/threonine kinase 1	Homo sapiens	42-45	
16973122-3	2006	Cu2+- and Zn2+-induced phosphorylation of Akt was blocked by phosphoinositide 3-kinase (PI3K) inhibitors, wortmannin and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	121-129	AKT serine/threonine kinase 1	Homo sapiens	42-45	
16973122-5	2006	Exposure to Cu2+ or Zn2+ elicited the subcellular redistribution of an overexpressed FoxO1a-EGFP fusion protein from nucleus to cytoplasm, which was not seen with a mutant FoxO1a form devoid of Akt phosphorylation sites.	cupric ion	12-16	forkhead box O1	Homo sapiens	85-91	
16973122-5	2006	Exposure to Cu2+ or Zn2+ elicited the subcellular redistribution of an overexpressed FoxO1a-EGFP fusion protein from nucleus to cytoplasm, which was not seen with a mutant FoxO1a form devoid of Akt phosphorylation sites.	cupric ion	12-16	forkhead box O1	Homo sapiens	172-178	
16973122-5	2006	Exposure to Cu2+ or Zn2+ elicited the subcellular redistribution of an overexpressed FoxO1a-EGFP fusion protein from nucleus to cytoplasm, which was not seen with a mutant FoxO1a form devoid of Akt phosphorylation sites.	cupric ion	12-16	AKT serine/threonine kinase 1	Homo sapiens	194-197	
16973122-5	2006	Exposure to Cu2+ or Zn2+ elicited the subcellular redistribution of an overexpressed FoxO1a-EGFP fusion protein from nucleus to cytoplasm, which was not seen with a mutant FoxO1a form devoid of Akt phosphorylation sites.	Zinc	20-24	forkhead box O1	Homo sapiens	85-91	
16973122-5	2006	Exposure to Cu2+ or Zn2+ elicited the subcellular redistribution of an overexpressed FoxO1a-EGFP fusion protein from nucleus to cytoplasm, which was not seen with a mutant FoxO1a form devoid of Akt phosphorylation sites.	Zinc	20-24	forkhead box O1	Homo sapiens	172-178	
16973122-5	2006	Exposure to Cu2+ or Zn2+ elicited the subcellular redistribution of an overexpressed FoxO1a-EGFP fusion protein from nucleus to cytoplasm, which was not seen with a mutant FoxO1a form devoid of Akt phosphorylation sites.	Zinc	20-24	AKT serine/threonine kinase 1	Homo sapiens	194-197	
16973122-7	2006	Likewise, the subcellular translocation from nucleus to cytoplasm of the Caenorhabditis elegans FoxO ortholog, DAF-16, was caused in starved worms exposed to copper ions.	Copper	158-164	Fork-head domain-containing protein;Forkhead box protein O	Caenorhabditis elegans	111-117	
16973122-8	2006	Activity of the promoter of the human glucose 6-phosphatase gene, known to be regulated by insulin and FoxO1a, was demonstrated in reporter gene assays to be attenuated in hepatoma cells exposed to Cu2+.	cupric ion	198-202	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	38-59	
16973122-8	2006	Activity of the promoter of the human glucose 6-phosphatase gene, known to be regulated by insulin and FoxO1a, was demonstrated in reporter gene assays to be attenuated in hepatoma cells exposed to Cu2+.	cupric ion	198-202	forkhead box O1	Homo sapiens	103-109	
16973122-10	2006	In summary, the PI3K/Akt pathway is activated in human hepatoma cells exposed to Cu2+ or Zn2+, resulting in the phosphorylation and subcellular relocalisation of transcription factor FoxO1a.	cupric ion	81-85	AKT serine/threonine kinase 1	Homo sapiens	21-24	
16973122-10	2006	In summary, the PI3K/Akt pathway is activated in human hepatoma cells exposed to Cu2+ or Zn2+, resulting in the phosphorylation and subcellular relocalisation of transcription factor FoxO1a.	cupric ion	81-85	forkhead box O1	Homo sapiens	183-189	
16973122-10	2006	In summary, the PI3K/Akt pathway is activated in human hepatoma cells exposed to Cu2+ or Zn2+, resulting in the phosphorylation and subcellular relocalisation of transcription factor FoxO1a.	Zinc	89-93	AKT serine/threonine kinase 1	Homo sapiens	21-24	
16973122-10	2006	In summary, the PI3K/Akt pathway is activated in human hepatoma cells exposed to Cu2+ or Zn2+, resulting in the phosphorylation and subcellular relocalisation of transcription factor FoxO1a.	Zinc	89-93	forkhead box O1	Homo sapiens	183-189