PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16968889-0	2007	Fetuin-A uptake in bovine vascular smooth muscle cells is calcium dependent and mediated by annexins.	Calcium	58-65	alpha 2-HS glycoprotein	Bos taurus	0-8	
16968889-4	2007	To examine the mechanism by which fetuin-A is taken up in bovine VSMC (BVSMC), we examined living cells by confocal microscopy and determined the uptake of Cy5-labeled fetuin-A.	bvsmc	71-76	alpha 2-HS glycoprotein	Bos taurus	34-42	
16968889-4	2007	To examine the mechanism by which fetuin-A is taken up in bovine VSMC (BVSMC), we examined living cells by confocal microscopy and determined the uptake of Cy5-labeled fetuin-A.	cyanine dye 5	156-159	alpha 2-HS glycoprotein	Bos taurus	168-176	
16968889-5	2007	The results demonstrated that fetuin-A was taken up in BVSMC only in the presence of extracellular calcium, whereas phosphorus had no effect.	bvsmc	55-60	alpha 2-HS glycoprotein	Bos taurus	30-38	
16968889-5	2007	The results demonstrated that fetuin-A was taken up in BVSMC only in the presence of extracellular calcium, whereas phosphorus had no effect.	Calcium	99-106	alpha 2-HS glycoprotein	Bos taurus	30-38	
16968889-6	2007	Additional studies demonstrated the calcium-dependent uptake was specific for fetuin-A and only observed in BVSMC and osteoblasts, but not epithelial, endothelial, or adipose cells.	Calcium	36-43	alpha 2-HS glycoprotein	Bos taurus	78-86	
16968889-8	2007	Fetuin-A also induced a sustained increase in intracellular calcium in BVSMC in the presence of extracellular calcium, whereas there was no increase in the absence of extracellular calcium.	Calcium	60-67	alpha 2-HS glycoprotein	Bos taurus	0-8	
16968889-8	2007	Fetuin-A also induced a sustained increase in intracellular calcium in BVSMC in the presence of extracellular calcium, whereas there was no increase in the absence of extracellular calcium.	bvsmc	71-76	alpha 2-HS glycoprotein	Bos taurus	0-8	
16968889-8	2007	Fetuin-A also induced a sustained increase in intracellular calcium in BVSMC in the presence of extracellular calcium, whereas there was no increase in the absence of extracellular calcium.	Calcium	110-117	alpha 2-HS glycoprotein	Bos taurus	0-8	
16968889-8	2007	Fetuin-A also induced a sustained increase in intracellular calcium in BVSMC in the presence of extracellular calcium, whereas there was no increase in the absence of extracellular calcium.	Calcium	110-117	alpha 2-HS glycoprotein	Bos taurus	0-8	
16968889-9	2007	To further characterize the uptake, we utilized an inhibitor of annexin calcium channel activity, demonstrating inhibition of both fetuin-A uptake and intracellular calcium increase.	Calcium	72-79	alpha 2-HS glycoprotein	Bos taurus	131-139	
16968889-10	2007	Finally, we demonstrate that fetuin-A binds to annexin II at the cell membrane of BVSMC.	bvsmc	82-87	alpha 2-HS glycoprotein	Bos taurus	29-37	
16968889-10	2007	Finally, we demonstrate that fetuin-A binds to annexin II at the cell membrane of BVSMC.	bvsmc	82-87	annexin A2	Bos taurus	47-57	
16968889-11	2007	In summary, our study demonstrates calcium- and annexin-dependent uptake of fetuin-A that leads to a sustained rise in intracellular calcium.	Calcium	35-42	alpha 2-HS glycoprotein	Bos taurus	76-84	
16968889-11	2007	In summary, our study demonstrates calcium- and annexin-dependent uptake of fetuin-A that leads to a sustained rise in intracellular calcium.	Calcium	133-140	alpha 2-HS glycoprotein	Bos taurus	76-84	
16968889-12	2007	This regulated uptake may be a mechanism by which fetuin-A inhibits VSMC calcification in the presence of excess calcium.	Calcium	113-120	alpha 2-HS glycoprotein	Bos taurus	50-58