PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16845181-0	2006	Nicotine enhances human vascular endothelial cell expression of ICAM-1 and VCAM-1 via protein kinase C, p38 mitogen-activated protein kinase, NF-kappaB, and AP-1.	Nicotine	0-8	vascular cell adhesion molecule 1	Homo sapiens	75-81	
16845181-3	2006	The aim of this study was to determine the effect of nicotine on the expression of the adhesion molecules, intercellular adhesion molecule (ICAM)-1 and vascular cell adhesion molecule (VCAM)-1 in endothelial cells and to determine the involvement of important known intermediaries, protein kinase C (PKC), p38 mitogen-activated protein kinase (p38 MAPK), and the transcription factors NF-kappaB and AP-1.	Nicotine	53-61	vascular cell adhesion molecule 1	Homo sapiens	152-192	
16845181-6	2006	We observed that nicotine increased the expression of ICAM-1 and VCAM-1 with a peak at 6 h. p38 MAPK was activated after 5 min exposure to 10-8 mol/L nicotine and returned to baseline levels by 30 min.	Nicotine	17-25	vascular cell adhesion molecule 1	Homo sapiens	65-71	
16845181-6	2006	We observed that nicotine increased the expression of ICAM-1 and VCAM-1 with a peak at 6 h. p38 MAPK was activated after 5 min exposure to 10-8 mol/L nicotine and returned to baseline levels by 30 min.	Nicotine	150-158	vascular cell adhesion molecule 1	Homo sapiens	65-71	
16845181-9	2006	Inhibitors of p38 MAPK, PKC, and NF-kappaB suppressed nicotine-stimulated expression of ICAM-1 and VCAM-1.	Nicotine	54-62	vascular cell adhesion molecule 1	Homo sapiens	99-105	
16845181-10	2006	Our results indicate that nicotine enhances the expression of ICAM-1 and VCAM-1 on the endothelial cell surface via a second messenger pathway which involves PKC and p38 MAPK-mediated activation of NF-kappaB and AP-1, resulting in increased expression of these cellular adhesion molecules.	Nicotine	26-34	vascular cell adhesion molecule 1	Homo sapiens	73-79