PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16813535-13 2006 RESULTS: The novel mutation introduces a premature stop codon in place of Lys-378 and thereby eliminates the entire p62 UBA domain; this and two additional natural mutations (P392L, E396X) increased NF-kappaB activation compared with wildtype p62. Lysine 74-77 sequestosome 1 Homo sapiens 116-119 16813535-13 2006 RESULTS: The novel mutation introduces a premature stop codon in place of Lys-378 and thereby eliminates the entire p62 UBA domain; this and two additional natural mutations (P392L, E396X) increased NF-kappaB activation compared with wildtype p62. Lysine 74-77 sequestosome 1 Homo sapiens 243-246