PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16762923-0 2006 Direct involvement of the small GTPase Rac in activation of the superoxide-producing NADPH oxidase Nox1. Superoxides 64-74 AKT serine/threonine kinase 1 Homo sapiens 39-42 16762923-4 2006 Electropermeabilized HeLa cells, ectopically expressing Nox1, Noxo1, and Noxa1, produce superoxide in a GTP-dependent manner, which is abrogated by expression of a mutant Noxa1(R103E), defective in Rac binding. Superoxides 88-98 AKT serine/threonine kinase 1 Homo sapiens 198-201 16762923-5 2006 Superoxide production in Nox1-expressing HeLa and Caco-2 cells is decreased by depletion or sequestration of Rac; on the other hand, it is enhanced by expression of the constitutively active Rac1(Q61L), but not by that of a mutant Rac1 with the A27K substitution, deficient in binding to Noxa1. Superoxides 0-10 AKT serine/threonine kinase 1 Homo sapiens 109-112