PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16751264-1	2006	Digoxin, a substrate of P-glycoprotein (Pgp) and cytochrome P450 3a (Cyp3a), was used to illustrate the inductive effects of pregnenolone-16alpha-carbonitrile (PCN), a ligand of the pregnane X receptor, on the absorption and disposition of [3H]digoxin in the vascularly perfused rat small intestine preparation.	Pregnenolone Carbonitrile	125-158	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	24-38	
16751264-3	2006	PCN pretreatment significantly decreased blood perfusate [3H]digoxin concentrations for both systemic and intraluminal administrations of [3H]digoxin due to increased Pgp levels.	Pregnenolone Carbonitrile	0-3	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	167-170	
16751264-4	2006	The apical secretion by Pgp increased at 90 min with PCN treatment, from 11.2 +/- 5.1% of dose to 20.1 +/- 8.6% of dose after systemic administration of [3H]digoxin; this increase was, however, statistically insignificant (P = 0.13) because of the high variability among preparations.	Pregnenolone Carbonitrile	53-56	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	24-27