PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16698078-1 2007 Urocortin (UCN) is a 40 amino acid peptide which is closely related to corticotropin-releasing hormone and binds with high affinity to both CRH type 1 and type 2 receptors. Urocortins 0-9 urocortin Homo sapiens 11-14 16698078-1 2007 Urocortin (UCN) is a 40 amino acid peptide which is closely related to corticotropin-releasing hormone and binds with high affinity to both CRH type 1 and type 2 receptors. Urocortins 0-9 corticotropin releasing hormone Homo sapiens 71-102 16698078-3 2007 This study was designed to investigate the cellular localization of UCN at the implantation site of the human blastocyst, as well as the regulation of the UCN promoter by two major intracellular signaling pathways, the cAMP/PKA and diacylglycerol/PKC pathways, in cells of placental origin. Cyclic AMP 219-223 urocortin Homo sapiens 155-158 16698078-3 2007 This study was designed to investigate the cellular localization of UCN at the implantation site of the human blastocyst, as well as the regulation of the UCN promoter by two major intracellular signaling pathways, the cAMP/PKA and diacylglycerol/PKC pathways, in cells of placental origin. Diglycerides 232-246 urocortin Homo sapiens 155-158 16698078-6 2007 Immunohistochemistry revealed expression of UCN in the cytotrophoblast, the EVT and decidual cells. EVT 76-79 urocortin Homo sapiens 44-47 16698078-7 2007 Both UCN mRNA and peptide were detectable in freshly isolated EVT. EVT 62-65 urocortin Homo sapiens 5-8 16698078-8 2007 Finally, a human UCN promoter luciferase reporter construct transfected into JEG3 cells was significantly inducible by phorbol ester plus ionomycin, but not by phorbol ester alone or by forskolin. Phorbol Esters 119-132 urocortin Homo sapiens 17-20 16698078-8 2007 Finally, a human UCN promoter luciferase reporter construct transfected into JEG3 cells was significantly inducible by phorbol ester plus ionomycin, but not by phorbol ester alone or by forskolin. Ionomycin 138-147 urocortin Homo sapiens 17-20 16698078-8 2007 Finally, a human UCN promoter luciferase reporter construct transfected into JEG3 cells was significantly inducible by phorbol ester plus ionomycin, but not by phorbol ester alone or by forskolin. Phorbol Esters 160-173 urocortin Homo sapiens 17-20 16698078-9 2007 Collectively, the present study reports the expression of UCN in EVT and the activation of the UCN gene promoter by the diacylglycerol/PKC pathway. EVT 65-68 urocortin Homo sapiens 58-61 16698078-9 2007 Collectively, the present study reports the expression of UCN in EVT and the activation of the UCN gene promoter by the diacylglycerol/PKC pathway. Diglycerides 120-134 urocortin Homo sapiens 58-61 16698078-9 2007 Collectively, the present study reports the expression of UCN in EVT and the activation of the UCN gene promoter by the diacylglycerol/PKC pathway. Diglycerides 120-134 urocortin Homo sapiens 95-98 16698078-10 2007 The functional significance of urocortin for the physiology of EVT requires further investigation. EVT 63-66 urocortin Homo sapiens 31-40