PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16687448-2	2006	Smith-Lemli-Opitz syndrome (SLOS) is caused by defects in 7-dehydrocholesterol reductase (DHCR7), an enzyme catalyzing the final step of cholesterol biosynthesis.	Cholesterol	67-78	7-dehydrocholesterol reductase	Homo sapiens	90-95	
16687448-5	2006	DHCR7 has previously been implicated to function as a positive regulator of Hh signaling that acts to regulate the cholesterol adduction of Hh ligand or to affect Hh signaling in the responding cell.	Cholesterol	115-126	7-dehydrocholesterol reductase	Homo sapiens	0-5	
16687448-7	2006	Our analysis also raises the possibility that the human condition SLOS is caused not only by disruption of the enzymatic role of DHCR7 as a reductase in cholesterol biosynthesis, but may also involve defects in DHCR7 resulting in derepression of Shh signaling.	Cholesterol	153-164	7-dehydrocholesterol reductase	Homo sapiens	129-134