PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16686544-2	2006	Activation of six human brain carbonic anhydrases (hCAs, EC 4.2.1.1), hCA I, II, IV, VA, VII, and XIV, with l-/d-phenylalanine was investigated kinetically and by X-ray crystallography.	l-/d-phenylalanine	108-126	carbonic anhydrase 1	Homo sapiens	70-75	
16686544-3	2006	l-Phe was a potent activator of isozymes I, II, and XIV (K(A)s of 13-240 nM), a weaker activator of hCA VA and VII (K(A)s of 9.8-10.9 microM), and a quite inefficient hCA IV activator (K(A) of 52 microM).	Phenylalanine	0-5	carbonic anhydrase 5A	Homo sapiens	100-114	
16686544-4	2006	d-Phe showed good hCA II activatory properties (K(A) of 35 nM), being a moderate hCA VA, VII, and XIV (K(A)s of 4.6-9.7 microM) and a weak hCA I and IV activator (K(A)s of 63-86 microM).	Phenylalanine	2-5	carbonic anhydrase 2	Homo sapiens	18-24	
16686544-4	2006	d-Phe showed good hCA II activatory properties (K(A) of 35 nM), being a moderate hCA VA, VII, and XIV (K(A)s of 4.6-9.7 microM) and a weak hCA I and IV activator (K(A)s of 63-86 microM).	Phenylalanine	2-5	carbonic anhydrase 5A	Homo sapiens	81-87	
16686544-4	2006	d-Phe showed good hCA II activatory properties (K(A) of 35 nM), being a moderate hCA VA, VII, and XIV (K(A)s of 4.6-9.7 microM) and a weak hCA I and IV activator (K(A)s of 63-86 microM).	Phenylalanine	2-5	carbonic anhydrase 1	Homo sapiens	18-23	
16686544-5	2006	X-ray crystallography of the hCA II-l-Phe/d-Phe adducts showed the activators to be anchored at the entrance of the active site, participating in numerous bonds and hydrophobic interactions with amino acid residues His64, Thr200, Trp5, and Pro201.	Phenylalanine	38-41	carbonic anhydrase 2	Homo sapiens	29-35	
16686544-5	2006	X-ray crystallography of the hCA II-l-Phe/d-Phe adducts showed the activators to be anchored at the entrance of the active site, participating in numerous bonds and hydrophobic interactions with amino acid residues His64, Thr200, Trp5, and Pro201.	Phenylalanine	38-41	transient receptor potential cation channel subfamily C member 5	Homo sapiens	230-234	
16686544-5	2006	X-ray crystallography of the hCA II-l-Phe/d-Phe adducts showed the activators to be anchored at the entrance of the active site, participating in numerous bonds and hydrophobic interactions with amino acid residues His64, Thr200, Trp5, and Pro201.	Phenylalanine	44-47	carbonic anhydrase 2	Homo sapiens	29-35	
16686544-5	2006	X-ray crystallography of the hCA II-l-Phe/d-Phe adducts showed the activators to be anchored at the entrance of the active site, participating in numerous bonds and hydrophobic interactions with amino acid residues His64, Thr200, Trp5, and Pro201.	Phenylalanine	44-47	transient receptor potential cation channel subfamily C member 5	Homo sapiens	230-234