PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16685393-3 2006 While IFN-alpha or COX-2 inhibitors alone did not result in growth inhibition of A549 cells, the combination of IFN-alpha and celecoxib or curcumin resulted in a significant growth inhibition of A549 cells, which was associated with down-regulation of CDK2, 4, and 6 and up-regulation of p27. Curcumin 139-147 cyclin dependent kinase 2 Homo sapiens 252-256