PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16670275-3	2006	In this study we show that IRF3-mediated ISG induction by LPS requires the production of reactive oxygen species (ROS) by the NADPH-dependent oxidase NOX4.	Reactive Oxygen Species	89-112	interferon regulatory factor 3	Homo sapiens	27-31	
16670275-3	2006	In this study we show that IRF3-mediated ISG induction by LPS requires the production of reactive oxygen species (ROS) by the NADPH-dependent oxidase NOX4.	Reactive Oxygen Species	89-112	NADPH oxidase 4	Homo sapiens	150-154	
16670275-3	2006	In this study we show that IRF3-mediated ISG induction by LPS requires the production of reactive oxygen species (ROS) by the NADPH-dependent oxidase NOX4.	Reactive Oxygen Species	114-117	interferon regulatory factor 3	Homo sapiens	27-31	
16670275-3	2006	In this study we show that IRF3-mediated ISG induction by LPS requires the production of reactive oxygen species (ROS) by the NADPH-dependent oxidase NOX4.	Reactive Oxygen Species	114-117	NADPH oxidase 4	Homo sapiens	150-154	
16670275-4	2006	Furthermore, we present evidence that LPS-mediated ROS production leads to activation of apoptosis-regulating-signal kinase (ASK) 1, a MAPK kinase kinase family member capable of activating the MAP kinase 6/p38 axis.	Reactive Oxygen Species	51-54	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	89-131	
16670275-4	2006	Furthermore, we present evidence that LPS-mediated ROS production leads to activation of apoptosis-regulating-signal kinase (ASK) 1, a MAPK kinase kinase family member capable of activating the MAP kinase 6/p38 axis.	Reactive Oxygen Species	51-54	mitogen-activated protein kinase 6	Homo sapiens	194-206	
16670275-4	2006	Furthermore, we present evidence that LPS-mediated ROS production leads to activation of apoptosis-regulating-signal kinase (ASK) 1, a MAPK kinase kinase family member capable of activating the MAP kinase 6/p38 axis.	Reactive Oxygen Species	51-54	mitogen-activated protein kinase 14	Homo sapiens	207-210	
16670275-6	2006	Thus, our results presented here suggest a novel role for ROS and ASK1 in the innate immune response as signaling intermediates in the IRF3 activation pathway.	Reactive Oxygen Species	58-61	interferon regulatory factor 3	Homo sapiens	135-139