PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16522817-0	2006	CD25 and indoleamine 2,3-dioxygenase are up-regulated by prostaglandin E2 and expressed by tumor-associated dendritic cells in vivo: additional mechanisms of T-cell inhibition.	Dinoprostone	57-73	interleukin 2 receptor subunit alpha	Homo sapiens	0-4	
16522817-4	2006	Here, we extend these findings, demonstrating a concomitant induction of IDO and secretion of soluble CD25 after DC maturation in the presence of PGE2.	Dinoprostone	146-150	interleukin 2 receptor subunit alpha	Homo sapiens	102-106	
16522817-5	2006	While maturation of DCs induced IDO expression on transcriptional level, only integration of PGE2 signaling led to up-regulation of functional IDO protein as well as significant expression of cell-surface and soluble CD25 protein.	Dinoprostone	93-97	interleukin 2 receptor subunit alpha	Homo sapiens	217-221	
16522817-7	2006	Of importance, we demonstrate that different carcinoma entities associated with elevated levels of PGE2 coexpress CD25 and IDO in peritumoral dendritic cells, suggesting that PGE2 might influence IDO expression in human DCs in the tumor environment.	Dinoprostone	99-103	interleukin 2 receptor subunit alpha	Homo sapiens	114-118	
16522817-7	2006	Of importance, we demonstrate that different carcinoma entities associated with elevated levels of PGE2 coexpress CD25 and IDO in peritumoral dendritic cells, suggesting that PGE2 might influence IDO expression in human DCs in the tumor environment.	Dinoprostone	175-179	interleukin 2 receptor subunit alpha	Homo sapiens	114-118