PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16513843-0 2006 Involvement of the ATR- and ATM-dependent checkpoint responses in cell cycle arrest evoked by pierisin-1. pierisin-1 94-104 ATR serine/threonine kinase Homo sapiens 19-22 16513843-0 2006 Involvement of the ATR- and ATM-dependent checkpoint responses in cell cycle arrest evoked by pierisin-1. pierisin-1 94-104 ATM serine/threonine kinase Homo sapiens 28-31 16513843-6 2006 In the colony survival assays, Rad17(-/-) DT40 cells showed greater sensitivity to pierisin-1-induced cytotoxicity than wild-type and ATM(-/-) DT40 cells, possibly due to defects of checkpoint responses, such as the Chk1 activation. pierisin-1 83-93 RAD17 checkpoint clamp loader component Gallus gallus 31-36 16513843-6 2006 In the colony survival assays, Rad17(-/-) DT40 cells showed greater sensitivity to pierisin-1-induced cytotoxicity than wild-type and ATM(-/-) DT40 cells, possibly due to defects of checkpoint responses, such as the Chk1 activation. pierisin-1 83-93 opsin, green sensitive (rhodopsin-like) Gallus gallus 216-220 16513843-8 2006 These results thus suggest that pierisin-1 treatment primarily activates ATR pathway and eventually activates ATM pathway as a result of the induction of apoptosis. pierisin-1 32-42 ATR serine/threonine kinase Homo sapiens 73-76 16513843-8 2006 These results thus suggest that pierisin-1 treatment primarily activates ATR pathway and eventually activates ATM pathway as a result of the induction of apoptosis. pierisin-1 32-42 ATM serine/threonine kinase Homo sapiens 110-113