PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16452470-0	2006	Prolonged activation of cAMP-response element-binding protein and ATF-2 needed for nicotine-triggered elevation of tyrosine hydroxylase gene transcription in PC12 cells.	Nicotine	83-91	cAMP responsive element binding protein 1	Rattus norvegicus	24-61	
16452470-1	2006	Phosphorylation (P-) of cAMP-response element-binding protein (CREB) by protein kinase A or mitogen-activated protein kinases was implicated in mediating the increased tyrosine hydroxylase (TH) gene expression after prolonged exposure to nicotine in vivo and in cell culture.	Nicotine	238-246	cAMP responsive element binding protein 1	Rattus norvegicus	24-61	
16452470-1	2006	Phosphorylation (P-) of cAMP-response element-binding protein (CREB) by protein kinase A or mitogen-activated protein kinases was implicated in mediating the increased tyrosine hydroxylase (TH) gene expression after prolonged exposure to nicotine in vivo and in cell culture.	Nicotine	238-246	cAMP responsive element binding protein 1	Rattus norvegicus	63-67	
16452470-3	2006	Treatment of PC12 cells with 200 microm nicotine triggered rapid but transient elevation of P-CREB followed by a second sustained rise after 2-5 h of continuous nicotine.	Nicotine	40-48	cAMP responsive element binding protein 1	Rattus norvegicus	94-98	
16452470-6	2006	In contrast, protein kinase A inhibitor H-89 or Ca(2+)/calmodulin-activated protein kinase inhibitor KN-93 reduced the nicotine-triggered rise in P-CREB and TH promoter activity.	Nicotine	119-127	cAMP responsive element binding protein 1	Rattus norvegicus	148-152	
16452470-11	2006	Knockdown of ATF-2 or CREB with siRNA did not alter basal TH promoter activity or mRNA but greatly attenuated the response to nicotine.	Nicotine	126-134	cAMP responsive element binding protein 1	Rattus norvegicus	22-26	
16452470-12	2006	The results suggest that both ATF-2 and CREB mediate activation of TH gene transcription by nicotine.	Nicotine	92-100	cAMP responsive element binding protein 1	Rattus norvegicus	40-44