PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16450077-4 2006 In the present study we show that interaction of the HDL-associated sphingosylphosphorylcholine and sphingosylgalactosyl-3-sulfate (lysosulfatide, LSF) with the G-protein-coupled EDG receptor initiates a signalling cascade that activates the protein kinase Akt and reduces the E-selectin, ICAM-1 and VCAM-1 expression on protein and mRNA level. psychosine-3'-sulfate ester 132-145 intercellular adhesion molecule 1 Homo sapiens 289-295