PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16407108-2	2006	For example, diastolic calcium "leak" via RyR2 channels in the sarcoplasmic reticulum has been identified as an important factor contributing to impaired contractility in heart failure and ventricular arrhythmias that cause sudden cardiac death.	Calcium	23-30	ryanodine receptor 2, cardiac	Mus musculus	42-46	
16407108-3	2006	In patients with heart failure, chronic activation of the "fight or flight" stress response leads to protein kinase A (PKA) hyperphosphorylation of RyR2 at Ser-2808.	Serine	156-159	ryanodine receptor 2	Homo sapiens	148-152	
16407108-4	2006	PKA phosphorylation of RyR2 Ser-2808 reduces the binding affinity of the channel-stabilizing subunit calstabin2, resulting in leaky RyR2 channels.	Serine	28-31	ryanodine receptor 2, cardiac	Mus musculus	23-27	
16407108-4	2006	PKA phosphorylation of RyR2 Ser-2808 reduces the binding affinity of the channel-stabilizing subunit calstabin2, resulting in leaky RyR2 channels.	Serine	28-31	FK506 binding protein 1b	Mus musculus	101-111	
16407108-4	2006	PKA phosphorylation of RyR2 Ser-2808 reduces the binding affinity of the channel-stabilizing subunit calstabin2, resulting in leaky RyR2 channels.	Serine	28-31	ryanodine receptor 2, cardiac	Mus musculus	132-136	
16407108-7	2006	Taken together, these data show that PKA phosphorylation of Ser-2808 on the RyR2 channel appears to be a critical mediator of progressive cardiac dysfunction after myocardial infarction.	Serine	60-63	ryanodine receptor 2, cardiac	Mus musculus	76-80