PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16402387-0	2006	Lysophosphatidic acid stimulates PC-3 prostate cancer cell Matrigel invasion through activation of RhoA and NF-kappaB activity.	lysophosphatidic acid	0-21	nuclear factor kappa B subunit 1	Homo sapiens	108-117	
16402387-1	2006	This study was performed to determine the relationship of lysophosphatidic acid (LPA) stimulation and increased Ras homolog A (RhoA) activity to nuclear factor kappa B (NF-kappaB) activity, and the role of these factors in regulating prostate cancer cell invasion.	lysophosphatidic acid	58-79	nuclear factor kappa B subunit 1	Homo sapiens	145-167	
16402387-1	2006	This study was performed to determine the relationship of lysophosphatidic acid (LPA) stimulation and increased Ras homolog A (RhoA) activity to nuclear factor kappa B (NF-kappaB) activity, and the role of these factors in regulating prostate cancer cell invasion.	lysophosphatidic acid	58-79	nuclear factor kappa B subunit 1	Homo sapiens	169-178	
16402387-3	2006	LPA treatment rapidly and transiently induced RhoA activity followed by maximally increased DNA binding of NF-kappaB at 1 h and AP-1 at 4 h. The LPA-induced NF-kappaB DNA binding was preceded by transient IkappaBalpha phosphorylation, and decreased total IkappaBalpha levels.	lysophosphatidic acid	0-3	nuclear factor kappa B subunit 1	Homo sapiens	107-116	
16402387-3	2006	LPA treatment rapidly and transiently induced RhoA activity followed by maximally increased DNA binding of NF-kappaB at 1 h and AP-1 at 4 h. The LPA-induced NF-kappaB DNA binding was preceded by transient IkappaBalpha phosphorylation, and decreased total IkappaBalpha levels.	lysophosphatidic acid	0-3	nuclear factor kappa B subunit 1	Homo sapiens	157-166	
16402387-3	2006	LPA treatment rapidly and transiently induced RhoA activity followed by maximally increased DNA binding of NF-kappaB at 1 h and AP-1 at 4 h. The LPA-induced NF-kappaB DNA binding was preceded by transient IkappaBalpha phosphorylation, and decreased total IkappaBalpha levels.	lysophosphatidic acid	145-148	nuclear factor kappa B subunit 1	Homo sapiens	107-116	
16402387-3	2006	LPA treatment rapidly and transiently induced RhoA activity followed by maximally increased DNA binding of NF-kappaB at 1 h and AP-1 at 4 h. The LPA-induced NF-kappaB DNA binding was preceded by transient IkappaBalpha phosphorylation, and decreased total IkappaBalpha levels.	lysophosphatidic acid	145-148	nuclear factor kappa B subunit 1	Homo sapiens	157-166	
16402387-8	2006	Each inhibitor blocked LPA-induced invasion while PDTC inhibited LPA-induced NF-kappaB and invasion to the greatest extent.	lysophosphatidic acid	65-68	nuclear factor kappa B subunit 1	Homo sapiens	77-86	
16402387-9	2006	These results point to a model where LPA stimulates RhoA and increased PC-3 prostate cancer cell invasion activity through an NF-kappaB-dependent pathway.	lysophosphatidic acid	37-40	nuclear factor kappa B subunit 1	Homo sapiens	126-135