PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16354680-7 2006 Knockdown of Raptor as well as activators of the LKB1/AMPK pathway, such as the widely used antidiabetic compound metformin, suppress IRS-1 Ser636/639 phosphorylation and reverse mTOR-mediated inhibition on PI3-kinase/Akt signaling. Metformin 114-123 insulin receptor substrate 1 Homo sapiens 134-139