PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16331685-2 2006 In this report we provide evidences that oleandrin, a cardiac glycoside potentially inhibited IL-8-, formyl peptide (FMLP)-, EGF-, or nerve growth factor (NGF)-, but not IL-1- or TNF-induced NF-kappaB activation in macrophages. oleandrin 41-50 C-X-C motif chemokine ligand 8 Homo sapiens 94-98 16331685-3 2006 Oleandrin inhibited IL-8-, but not TNF-induced NF-kappaB-dependent genes expression. oleandrin 0-9 C-X-C motif chemokine ligand 8 Homo sapiens 20-24 16331685-4 2006 Oleandrin inhibited the binding of IL-8, EGF, or NGF, but not IL-1 or TNF. oleandrin 0-9 C-X-C motif chemokine ligand 8 Homo sapiens 35-39 16331685-7 2006 Phospholipids significantly protected oleandrin-mediated inhibition of IL-8 binding thereby restoring IL-8-induced NF-kappaB activation. oleandrin 38-47 C-X-C motif chemokine ligand 8 Homo sapiens 71-75 16331685-7 2006 Phospholipids significantly protected oleandrin-mediated inhibition of IL-8 binding thereby restoring IL-8-induced NF-kappaB activation. oleandrin 38-47 C-X-C motif chemokine ligand 8 Homo sapiens 102-106 16331685-9 2006 Overall, our results suggest that oleandrin inhibits IL-8-mediated biological responses in diverse cell types by modulating IL-8Rs through altering membrane fluidity and microviscosity. oleandrin 34-43 C-X-C motif chemokine ligand 8 Homo sapiens 53-57