PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16210602-0	2005	Chronic morphine treatment promotes specific Th2 cytokine production by murine T cells in vitro via a Fas/Fas ligand-dependent mechanism.	Morphine	8-16	heart and neural crest derivatives expressed 2	Mus musculus	45-48	
16210602-0	2005	Chronic morphine treatment promotes specific Th2 cytokine production by murine T cells in vitro via a Fas/Fas ligand-dependent mechanism.	Morphine	8-16	Fas ligand (TNF superfamily, member 6)	Mus musculus	106-116	
16210602-3	2005	Although chronic morphine administration has been shown to selectively promote Th2 development in unpurified T cell populations, the direct effects of chronic morphine on Th cell skewing and cytokine production by CD4(+) T cells have not been elucidated.	Morphine	17-25	heart and neural crest derivatives expressed 2	Mus musculus	79-82	
16210602-3	2005	Although chronic morphine administration has been shown to selectively promote Th2 development in unpurified T cell populations, the direct effects of chronic morphine on Th cell skewing and cytokine production by CD4(+) T cells have not been elucidated.	Morphine	159-167	CD4 antigen	Mus musculus	214-217	
16210602-6	2005	Therefore, we analyzed whether the ability of morphine to affect Th2 cytokine production was mediated by regulation of Fas, FasL, and TRAIL expression and AICD directly in purified Th cells.	Morphine	46-54	heart and neural crest derivatives expressed 2	Mus musculus	65-68	
16210602-6	2005	Therefore, we analyzed whether the ability of morphine to affect Th2 cytokine production was mediated by regulation of Fas, FasL, and TRAIL expression and AICD directly in purified Th cells.	Morphine	46-54	Fas ligand (TNF superfamily, member 6)	Mus musculus	124-128	
16210602-6	2005	Therefore, we analyzed whether the ability of morphine to affect Th2 cytokine production was mediated by regulation of Fas, FasL, and TRAIL expression and AICD directly in purified Th cells.	Morphine	46-54	tumor necrosis factor (ligand) superfamily, member 10	Mus musculus	134-139	
16210602-7	2005	We found that morphine significantly promoted IL-4 and IL-13 production but did not alter IL-5 or IFN-gamma.	Morphine	14-22	interleukin 4	Mus musculus	46-50	
16210602-7	2005	We found that morphine significantly promoted IL-4 and IL-13 production but did not alter IL-5 or IFN-gamma.	Morphine	14-22	interleukin 13	Mus musculus	55-60	
16210602-8	2005	Furthermore, morphine enhanced the mRNA expression of Fas, FasL and TRAIL and promoted Fas-mediated AICD of CD4(+) T cells.	Morphine	13-21	Fas ligand (TNF superfamily, member 6)	Mus musculus	59-63	
16210602-8	2005	Furthermore, morphine enhanced the mRNA expression of Fas, FasL and TRAIL and promoted Fas-mediated AICD of CD4(+) T cells.	Morphine	13-21	tumor necrosis factor (ligand) superfamily, member 10	Mus musculus	68-73	
16210602-8	2005	Furthermore, morphine enhanced the mRNA expression of Fas, FasL and TRAIL and promoted Fas-mediated AICD of CD4(+) T cells.	Morphine	13-21	CD4 antigen	Mus musculus	108-111	
16210602-9	2005	Additionally, blockade of Fas/FasL interaction by anti-FasL inhibited the morphine-induced production of IL-4 and IL-13 and AICD of CD4(+) T cells.	Morphine	74-82	Fas ligand (TNF superfamily, member 6)	Mus musculus	30-34	
16210602-9	2005	Additionally, blockade of Fas/FasL interaction by anti-FasL inhibited the morphine-induced production of IL-4 and IL-13 and AICD of CD4(+) T cells.	Morphine	74-82	Fas ligand (TNF superfamily, member 6)	Mus musculus	55-59	
16210602-9	2005	Additionally, blockade of Fas/FasL interaction by anti-FasL inhibited the morphine-induced production of IL-4 and IL-13 and AICD of CD4(+) T cells.	Morphine	74-82	interleukin 4	Mus musculus	105-109	
16210602-9	2005	Additionally, blockade of Fas/FasL interaction by anti-FasL inhibited the morphine-induced production of IL-4 and IL-13 and AICD of CD4(+) T cells.	Morphine	74-82	interleukin 13	Mus musculus	114-119	
16210602-9	2005	Additionally, blockade of Fas/FasL interaction by anti-FasL inhibited the morphine-induced production of IL-4 and IL-13 and AICD of CD4(+) T cells.	Morphine	74-82	CD4 antigen	Mus musculus	132-135	
16210602-10	2005	These results suggest that morphine preferentially enhances Th2 cell differentiation via killing of Th1 cells in a Fas/FasL-dependent manner.	Morphine	27-35	heart and neural crest derivatives expressed 2	Mus musculus	60-63	
16210602-10	2005	These results suggest that morphine preferentially enhances Th2 cell differentiation via killing of Th1 cells in a Fas/FasL-dependent manner.	Morphine	27-35	negative elongation factor complex member C/D, Th1l	Mus musculus	100-103	
16210602-10	2005	These results suggest that morphine preferentially enhances Th2 cell differentiation via killing of Th1 cells in a Fas/FasL-dependent manner.	Morphine	27-35	Fas ligand (TNF superfamily, member 6)	Mus musculus	119-123