PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16192836-0	2005	Effect of valproate on plasma levels of interleukin-6 in healthy male humans.	Valproic Acid	10-19	interleukin 6	Homo sapiens	40-53	
16192836-2	2005	The present study aimed to determine whether there is a treatment effect of valproate on plasma levels of the pro-inflammatory cytokine, interleukin (IL)-6, in healthy male humans.	Valproic Acid	76-85	interleukin 6	Homo sapiens	137-155	
16192836-3	2005	Plasma levels of IL-6 were measured in 10 healthy male humans before and after 7 days of treatment with 1000 mg per day of valproate (i.e. 500 mg in the morning and 500 mg in the evening).	Valproic Acid	123-132	interleukin 6	Homo sapiens	17-21	
16192836-9	2005	We found a significant increase in plasma levels of IL-6 after the 7 days of valproate treatment in healthy male subjects.	Valproic Acid	77-86	interleukin 6	Homo sapiens	52-56	
16192836-10	2005	Furthermore, there was a significant positive correlation between the changes in plasma IL-6 and blood levels of valproic acid.	Valproic Acid	113-126	interleukin 6	Homo sapiens	88-92	
16192836-11	2005	The findings of this study are consistent with previous studies on subjects with epilepsy, suggesting a modulating effect of valproate on the pro-inflammatory cytokine IL-6 in humans.	Valproic Acid	125-134	interleukin 6	Homo sapiens	168-172