PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16157224-2 2005 Here we demonstrate that the sulfate groups at C6/N and especially C6, but not C2 and C3, of heparin play a critical role in P-selectin recognition and that 2-O,3-O-desulfated heparin can block P-selectin-mediated A375 human melanoma cell adhesion. hippuric acid 157-160 selectin P Homo sapiens 194-204 16157224-3 2005 Our findings show that chemical modification of heparin, especially 2-O,3-O-desulfation, may result in a therapeutic agent that is anti-metastatic because it blocks unwanted P-selectin-dependent adhesion but that lacks dose-limiting anticoagulant effects. hippuric acid 68-71 selectin P Homo sapiens 174-184