PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15988024-8 2005 Despite their separate functions in silencing and SAGA-mediated transcription, respectively, deletion of both UBP10 and UBP8 results in a synergistic increase in the steady-state levels of H2B ubiquitination and in the number of genes with altered expression, indicating that Ubp10p and Ubp8p likely overlap in some of their target chromatin regions. ubp8 120-124 H2B clustered histone 21 Homo sapiens 189-192