PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 1593712-0 1992 Phospholipase C activation by endothelin-1 and noradrenaline in isolated penile erectile tissue from rabbit. Norepinephrine 47-60 LOC100009319 Oryctolagus cuniculus 0-15 1593712-1 1992 The effects of endothelin-1 and noradrenaline on phospholipase C activity in the rabbit isolated corpus cavernosum were investigated by measuring the accumulation of inositol phosphates. Norepinephrine 32-45 LOC100009319 Oryctolagus cuniculus 49-64 1593712-2 1992 Both endothelin-1 and noradrenaline caused a time- and concentration-dependent increase in the accumulation of 3H-inositol phosphates in preparations prelabelled with 3H-myo-inositol. 3h-inositol phosphates 111-133 endothelin-1 Oryctolagus cuniculus 5-17 1593712-2 1992 Both endothelin-1 and noradrenaline caused a time- and concentration-dependent increase in the accumulation of 3H-inositol phosphates in preparations prelabelled with 3H-myo-inositol. 3h-myo-inositol 167-182 endothelin-1 Oryctolagus cuniculus 5-17 1593712-4 1992 At 60 minutes, the mean increases in 3H-inositol inositol phosphates induced by 3 x 10(-7) M endothelin-1 and 10(-3) M noradrenaline amounted to 341 and 530% of time-matched controls, respectively. 3h-inositol inositol phosphates 37-68 endothelin-1 Oryctolagus cuniculus 93-112 1593712-4 1992 At 60 minutes, the mean increases in 3H-inositol inositol phosphates induced by 3 x 10(-7) M endothelin-1 and 10(-3) M noradrenaline amounted to 341 and 530% of time-matched controls, respectively. Norepinephrine 119-132 endothelin-1 Oryctolagus cuniculus 93-112 1593712-9 1992 The results suggest that exogenous endothelin-1 and noradrenaline activate phospholipase C in corpus cavernosum, and that this mechanism is partly independent of extracellular Ca2+. Norepinephrine 52-65 LOC100009319 Oryctolagus cuniculus 75-90