PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15919766-2 2005 Recent studies in our laboratory have shown that the nuclear receptor pregnane X receptor (PXR) is important in the transcriptional activation of the CYP2C9 promoter by drugs such as rifampicin and that the essential element is a constitutive androstane receptor (CAR)/PXR site -1839 bp upstream of the translation start site. Rifampin 183-193 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 150-156 15919766-8 2005 Mutation of the two HNF4alpha binding sites differentially prevented up-regulation of CYP2C9 promoter by both CAR as well as HNF4alpha, synergy between the two receptors, and essentially abolished induction by rifampicin in HepG2 cells transfected with PXR. Rifampin 210-220 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 86-92