PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15805289-6 2005 Consequently, PC3 cells were sensitized to the killing effects of the DNA-damaging drug doxorubicin. Doxorubicin 88-99 proprotein convertase subtilisin/kexin type 1 Homo sapiens 14-17 15805289-7 2005 Combining ATM knockdown with the Chk1 inhibitor UCN-01 further increased doxorubicin sensitivity in these cells. Doxorubicin 73-84 ATM serine/threonine kinase Homo sapiens 10-13 15805289-7 2005 Combining ATM knockdown with the Chk1 inhibitor UCN-01 further increased doxorubicin sensitivity in these cells. Doxorubicin 73-84 checkpoint kinase 1 Homo sapiens 33-37 15805289-7 2005 Combining ATM knockdown with the Chk1 inhibitor UCN-01 further increased doxorubicin sensitivity in these cells. Doxorubicin 73-84 urocortin Homo sapiens 48-51 15805289-9 2005 However, IMR90 and LNCaP cells became more sensitive to doxorubicin or doxorubicin plus UCN-01 when both p53 and ATM functions were suppressed. Doxorubicin 56-67 tumor protein p53 Homo sapiens 105-108 15805289-9 2005 However, IMR90 and LNCaP cells became more sensitive to doxorubicin or doxorubicin plus UCN-01 when both p53 and ATM functions were suppressed. Doxorubicin 56-67 ATM serine/threonine kinase Homo sapiens 113-116 15805289-9 2005 However, IMR90 and LNCaP cells became more sensitive to doxorubicin or doxorubicin plus UCN-01 when both p53 and ATM functions were suppressed. Doxorubicin 71-82 tumor protein p53 Homo sapiens 105-108 15805289-9 2005 However, IMR90 and LNCaP cells became more sensitive to doxorubicin or doxorubicin plus UCN-01 when both p53 and ATM functions were suppressed. Doxorubicin 71-82 ATM serine/threonine kinase Homo sapiens 113-116 15805289-10 2005 In addition, knockdown of the G(2) checkpoint regulators ATR and Chk1 also sensitized PC3 cells to doxorubicin and increased the expression of the E2F target gene PCNA. Doxorubicin 99-110 ATR serine/threonine kinase Homo sapiens 57-60 15805289-10 2005 In addition, knockdown of the G(2) checkpoint regulators ATR and Chk1 also sensitized PC3 cells to doxorubicin and increased the expression of the E2F target gene PCNA. Doxorubicin 99-110 checkpoint kinase 1 Homo sapiens 65-69 15805289-10 2005 In addition, knockdown of the G(2) checkpoint regulators ATR and Chk1 also sensitized PC3 cells to doxorubicin and increased the expression of the E2F target gene PCNA. Doxorubicin 99-110 proprotein convertase subtilisin/kexin type 1 Homo sapiens 86-89