PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15780952-0 2005 IL-1-induced receptor activator of NF-kappa B ligand in human periodontal ligament cells involves ERK-dependent PGE2 production. Dinoprostone 112-116 mitogen-activated protein kinase 1 Homo sapiens 98-101 15780952-9 2005 IL-1alpha activated ERK phosphorylation and PD98059 greatly inhibited both COX-2 mRNA expression and PGE(2) production induced by IL-1alpha in PDL cells. Dinoprostone 101-107 mitogen-activated protein kinase 1 Homo sapiens 20-23 15780952-11 2005 These results suggest that IL-1alpha stimulates osteoclast formation by increasing the expression level of RANKL versus OPG via ERK-dependent PGE2 production in PDL cells. Dinoprostone 142-146 mitogen-activated protein kinase 1 Homo sapiens 128-131