PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15697073-5	2004	The mean IGF-I levels decreased significantly on metformin therapy.	Metformin	49-58	insulin like growth factor 1	Homo sapiens	9-14	
15697073-7	2004	Only the change in serum levels of progesterone and IGF-I on metformin were statistically significant between responders and non-responders; metformin-induced decremental change in IGF-I levels were greater in responders.	Metformin	61-70	insulin like growth factor 1	Homo sapiens	52-57	
15697073-7	2004	Only the change in serum levels of progesterone and IGF-I on metformin were statistically significant between responders and non-responders; metformin-induced decremental change in IGF-I levels were greater in responders.	Metformin	141-150	insulin like growth factor 1	Homo sapiens	181-186	
15697073-9	2004	By decreasing insulin and IGF-I levels, metformin therapy offers additional beneficial effects in resumption of regular menses.	Metformin	40-49	insulin like growth factor 1	Homo sapiens	26-31	
15697073-10	2004	Thus, in PCOS patients with elevated levels of IGF-I, metformin may be considered as an appropriate agent to be used for the regulation of menstrual cycles.	Metformin	54-63	insulin like growth factor 1	Homo sapiens	47-52