PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15632127-5 2005 In addition, IGF-I activated Akt while inhibiting caspase-3 activation, and these effects were reversed by the PI3K inhibitors LY 294002 and wortmannin, but not by the MEK1 inhibitor PD 98059. Wortmannin 141-151 caspase 3 Homo sapiens 50-59