PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15608135-0	2005	Selective inhibition of human cytochrome P4502C8 by montelukast.	montelukast	52-63	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	30-48	
15608135-1	2005	The leukotriene receptor antagonist montelukast was examined for its inhibition of the human drug-metabolizing enzyme cytochrome P4502C8 (CYP2C8).	montelukast	36-47	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	118-136	
15608135-1	2005	The leukotriene receptor antagonist montelukast was examined for its inhibition of the human drug-metabolizing enzyme cytochrome P4502C8 (CYP2C8).	montelukast	36-47	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	138-144	
15608135-2	2005	Montelukast was demonstrated to be a potent inhibitor of CYP2C8-catalyzed amodiaquine N-deethylase, rosiglitazone N-demethylase, and paclitaxel 6alpha-hydroxylase in human liver microsomes.	montelukast	0-11	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	57-63	
15608135-8	2005	Montelukast was a selective inhibitor for human CYP2C8; inhibition of other human cytochrome P450 enzymes was substantially less.	montelukast	0-11	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	48-54	
15608135-9	2005	These in vitro data support the use of montelukast as a selective CYP2C8 inhibitor that could be used to determine the contribution of this enzyme to drug metabolism reactions.	montelukast	39-50	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	66-72	
15608135-10	2005	These data also raise the possibility that montelukast could have an effect on the metabolic clearance of drugs possessing CYP2C8-catalyzed metabolism as a major clearance pathway, thereby eliciting pharmacokinetic drug-drug interactions.	montelukast	43-54	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	123-129