PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15525582-1	2004	Glucose transporter 1 (GLUT1) plays an important role in the transport of glucose in the placenta.	Glucose	74-81	solute carrier family 2 member 1	Rattus norvegicus	0-21	
15525582-1	2004	Glucose transporter 1 (GLUT1) plays an important role in the transport of glucose in the placenta.	Glucose	74-81	solute carrier family 2 member 1	Rattus norvegicus	23-28	
15525582-2	2004	During early pregnancy, placentation occurs in a relatively hypoxic environment that is essential for appropriate embryonic development, and GLUT1 expression is enhanced in response to oxygen deficiency in the placenta.	Oxygen	185-191	solute carrier family 2 member 1	Rattus norvegicus	141-146	
15525582-5	2004	GLUT1 mRNA and protein expression were elevated under 5% O2 or in the presence of cobalt chloride, which has been shown to mimic hypoxia.	Oxygen	57-59	solute carrier family 2 member 1	Rattus norvegicus	0-5	
15525582-5	2004	GLUT1 mRNA and protein expression were elevated under 5% O2 or in the presence of cobalt chloride, which has been shown to mimic hypoxia.	cobaltous chloride	82-97	solute carrier family 2 member 1	Rattus norvegicus	0-5	
15525582-7	2004	Deletion mutant analysis of the rGLUT1 promoter indicated that a 184 bp hypoxia-responsive element (HRE) of the promoter was essential to increase GLUT1 reporter gene expression in response to low-oxygen conditions.	Oxygen	197-203	solute carrier family 2 member 1	Rattus norvegicus	32-38	
15525582-7	2004	Deletion mutant analysis of the rGLUT1 promoter indicated that a 184 bp hypoxia-responsive element (HRE) of the promoter was essential to increase GLUT1 reporter gene expression in response to low-oxygen conditions.	Oxygen	197-203	solute carrier family 2 member 1	Rattus norvegicus	33-38	
15525582-8	2004	BeWo and Rcho-1 cells cultured under 5% O2 or with CoCl2 showed increased expression of HIF-1alpha protein compared with those cultured under 20% O2.	Oxygen	40-42	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	88-98	
15525582-8	2004	BeWo and Rcho-1 cells cultured under 5% O2 or with CoCl2 showed increased expression of HIF-1alpha protein compared with those cultured under 20% O2.	cobaltous chloride	51-56	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	88-98	
15525582-10	2004	Exogeneous HIF-1alpha markedly increased the GLUT1 promoter activity from constructs containing the HRE site, while the GLUT1 promoter constructs lacking the HRE site were not activated by exogenous HIF-1alpha These data demonstrate that GLUT1 is up-regulated under 5% O2 or in the presence of CoCl2 in the placental cell lines through HIF-1alpha interaction with a consensus HRE site of the GLUT1 promoter.	Oxygen	269-271	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	11-21	
15525582-10	2004	Exogeneous HIF-1alpha markedly increased the GLUT1 promoter activity from constructs containing the HRE site, while the GLUT1 promoter constructs lacking the HRE site were not activated by exogenous HIF-1alpha These data demonstrate that GLUT1 is up-regulated under 5% O2 or in the presence of CoCl2 in the placental cell lines through HIF-1alpha interaction with a consensus HRE site of the GLUT1 promoter.	cobaltous chloride	294-299	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	11-21