PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15501038-7 2004 It has been observed that among all these isozymes, hCA V has the lowest affinity for bicarbonate and carbonate (K(i)"s in the range of 82-95 mM), which may represent an evolutionary adaptation of this isozyme to the rather alkaline environment (pH 8.5) within the mitochondria, where hCA V plays important functions in some biosynthetic reactions involving carboxylating enzymes (pyruvate carboxylase and acetyl coenzyme A carboxylase). Carbonates 88-97 carbonic anhydrase 5A Homo sapiens 52-57 15501038-7 2004 It has been observed that among all these isozymes, hCA V has the lowest affinity for bicarbonate and carbonate (K(i)"s in the range of 82-95 mM), which may represent an evolutionary adaptation of this isozyme to the rather alkaline environment (pH 8.5) within the mitochondria, where hCA V plays important functions in some biosynthetic reactions involving carboxylating enzymes (pyruvate carboxylase and acetyl coenzyme A carboxylase). Carbonates 88-97 carbonic anhydrase 5A Homo sapiens 285-290