PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15501038-1	2004	The membrane-associated human isozyme of carbonic anhydrase, hCA IV, has been investigated for its interaction with anion inhibitors, for the CO(2) hydration reaction catalyzed by this enzyme.	co(2)	142-147	carbonic anhydrase 4	Homo sapiens	61-67	
15501038-4	2004	Sulfate was a good hCA IV inhibitor (K(i) of 9 mM), although it is a much weaker inhibitor of isozymes I, II, V and IX.	Sulfates	0-7	carbonic anhydrase 4	Homo sapiens	19-25	
15501038-5	2004	Excellent hCA IV inhibitory properties showed sulfamic acid, sulfamide, phenylboronic acid and phenylarsonic acid, with K(i)"s in the range of 0.87-0.93 microM, whereas their affinities for the other investigated isozymes were in the millimolar range.	sulfamic acid	46-59	carbonic anhydrase 4	Homo sapiens	10-16	
15501038-5	2004	Excellent hCA IV inhibitory properties showed sulfamic acid, sulfamide, phenylboronic acid and phenylarsonic acid, with K(i)"s in the range of 0.87-0.93 microM, whereas their affinities for the other investigated isozymes were in the millimolar range.	fusarubin	61-70	carbonic anhydrase 4	Homo sapiens	10-16	
15501038-5	2004	Excellent hCA IV inhibitory properties showed sulfamic acid, sulfamide, phenylboronic acid and phenylarsonic acid, with K(i)"s in the range of 0.87-0.93 microM, whereas their affinities for the other investigated isozymes were in the millimolar range.	benzeneboronic acid	72-90	carbonic anhydrase 4	Homo sapiens	10-16	
15501038-5	2004	Excellent hCA IV inhibitory properties showed sulfamic acid, sulfamide, phenylboronic acid and phenylarsonic acid, with K(i)"s in the range of 0.87-0.93 microM, whereas their affinities for the other investigated isozymes were in the millimolar range.	benzenearsonic acid	95-113	carbonic anhydrase 4	Homo sapiens	10-16	
15501038-7	2004	It has been observed that among all these isozymes, hCA V has the lowest affinity for bicarbonate and carbonate (K(i)"s in the range of 82-95 mM), which may represent an evolutionary adaptation of this isozyme to the rather alkaline environment (pH 8.5) within the mitochondria, where hCA V plays important functions in some biosynthetic reactions involving carboxylating enzymes (pyruvate carboxylase and acetyl coenzyme A carboxylase).	Bicarbonates	86-97	carbonic anhydrase 5A	Homo sapiens	52-57	
15501038-7	2004	It has been observed that among all these isozymes, hCA V has the lowest affinity for bicarbonate and carbonate (K(i)"s in the range of 82-95 mM), which may represent an evolutionary adaptation of this isozyme to the rather alkaline environment (pH 8.5) within the mitochondria, where hCA V plays important functions in some biosynthetic reactions involving carboxylating enzymes (pyruvate carboxylase and acetyl coenzyme A carboxylase).	Bicarbonates	86-97	carbonic anhydrase 5A	Homo sapiens	285-290	
15501038-7	2004	It has been observed that among all these isozymes, hCA V has the lowest affinity for bicarbonate and carbonate (K(i)"s in the range of 82-95 mM), which may represent an evolutionary adaptation of this isozyme to the rather alkaline environment (pH 8.5) within the mitochondria, where hCA V plays important functions in some biosynthetic reactions involving carboxylating enzymes (pyruvate carboxylase and acetyl coenzyme A carboxylase).	Bicarbonates	86-97	pyruvate carboxylase	Homo sapiens	381-401	
15501038-7	2004	It has been observed that among all these isozymes, hCA V has the lowest affinity for bicarbonate and carbonate (K(i)"s in the range of 82-95 mM), which may represent an evolutionary adaptation of this isozyme to the rather alkaline environment (pH 8.5) within the mitochondria, where hCA V plays important functions in some biosynthetic reactions involving carboxylating enzymes (pyruvate carboxylase and acetyl coenzyme A carboxylase).	Carbonates	88-97	carbonic anhydrase 5A	Homo sapiens	52-57	
15501038-7	2004	It has been observed that among all these isozymes, hCA V has the lowest affinity for bicarbonate and carbonate (K(i)"s in the range of 82-95 mM), which may represent an evolutionary adaptation of this isozyme to the rather alkaline environment (pH 8.5) within the mitochondria, where hCA V plays important functions in some biosynthetic reactions involving carboxylating enzymes (pyruvate carboxylase and acetyl coenzyme A carboxylase).	Carbonates	88-97	carbonic anhydrase 5A	Homo sapiens	285-290	
15501038-7	2004	It has been observed that among all these isozymes, hCA V has the lowest affinity for bicarbonate and carbonate (K(i)"s in the range of 82-95 mM), which may represent an evolutionary adaptation of this isozyme to the rather alkaline environment (pH 8.5) within the mitochondria, where hCA V plays important functions in some biosynthetic reactions involving carboxylating enzymes (pyruvate carboxylase and acetyl coenzyme A carboxylase).	Carbonates	88-97	pyruvate carboxylase	Homo sapiens	381-401