PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15492267-3 2004 This negative regulation was established by showing that the PMA-induced macrophage phenotype, but not PMA-associated replication arrest, was abrogated (a) by replenishing the PMA-evoked decrease in cellular spermine levels with this polyamine from an exogenous source and (b) by blocking PMA-induced expression of the polyamine catabolic enzyme N(1)-spermidine/spermine acetyltransferase (SSAT) with antisense oligonucleotides in the presence of low substrate level. Polyamines 234-243 spermidine/spermine N1-acetyltransferase 1 Homo sapiens 346-388 15492267-3 2004 This negative regulation was established by showing that the PMA-induced macrophage phenotype, but not PMA-associated replication arrest, was abrogated (a) by replenishing the PMA-evoked decrease in cellular spermine levels with this polyamine from an exogenous source and (b) by blocking PMA-induced expression of the polyamine catabolic enzyme N(1)-spermidine/spermine acetyltransferase (SSAT) with antisense oligonucleotides in the presence of low substrate level. Polyamines 234-243 spermidine/spermine N1-acetyltransferase 1 Homo sapiens 390-394