PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15492260-4 2004 In two melanomas with wild-type p53 but with differential expression of APAF-1, treatment with camptothecin, celecoxib, or an nitric oxide synthase inhibitor (1400W) significantly modulated expression of 36 of 96 genes in an apoptosis-specific cDNA macroarray, but APAF-1 mRNA levels were not induced (in APAF-1(-) cells) nor up-regulated (in APAF-1(+) cells), a finding confirmed at the protein level. Celecoxib 109-118 tumor protein p53 Homo sapiens 32-35