PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15199168-1 2004 MutY homolog (MUTYH) excises adenine opposite 8-oxoguanine (8-oxoG) in DNA, thus preventing occurrence of G:C to T:A transversion. Adenine 29-36 mutY DNA glycosylase Mus musculus 14-19 15199168-1 2004 MutY homolog (MUTYH) excises adenine opposite 8-oxoguanine (8-oxoG) in DNA, thus preventing occurrence of G:C to T:A transversion. 8-hydroxyguanine 46-58 mutY DNA glycosylase Mus musculus 14-19 15199168-1 2004 MutY homolog (MUTYH) excises adenine opposite 8-oxoguanine (8-oxoG) in DNA, thus preventing occurrence of G:C to T:A transversion. 8-hydroxyguanine 60-66 mutY DNA glycosylase Mus musculus 14-19 15199168-2 2004 In cell-free extract prepared from the thymocytes of wild type but not MUTYH-null mice, adenine opposite 8-oxoG in DNA was excised by MUTYH, however, the generated apurinic (AP) site opposite 8-oxoG mostly remained unincised. Adenine 88-95 mutY DNA glycosylase Mus musculus 134-139 15199168-3 2004 Recombinant mouse MUTYH (mMUTYH) efficiently excised adenine opposite 8-oxoG and prevented mouse AP endonuclease (mAPEX1) from incising the generated AP site. Adenine 53-60 mutY DNA glycosylase Mus musculus 18-23 15199168-3 2004 Recombinant mouse MUTYH (mMUTYH) efficiently excised adenine opposite 8-oxoG and prevented mouse AP endonuclease (mAPEX1) from incising the generated AP site. Adenine 53-60 mutY DNA glycosylase Mus musculus 25-31 15199168-4 2004 In contrast, an AP site opposite 8-oxoG created by uracil DNA glycosylase or tetrahydrofuran opposite 8-oxoG was efficiently incised by mAPEX1 in the presence of an excess amount of mMUTYH. tetrahydrofuran 77-92 apurinic/apyrimidinic endonuclease 1 Mus musculus 136-142 15199168-4 2004 In contrast, an AP site opposite 8-oxoG created by uracil DNA glycosylase or tetrahydrofuran opposite 8-oxoG was efficiently incised by mAPEX1 in the presence of an excess amount of mMUTYH. tetrahydrofuran 77-92 mutY DNA glycosylase Mus musculus 182-188 15199168-5 2004 Mutant mMUTYH with R361A or G365D substitution, excised adenine opposite 8-oxoG as efficiently as did wild-type mMUTYH, but failed to prevent mAPEX1 from incising the generated AP site. Adenine 56-63 mutY DNA glycosylase Mus musculus 7-13 15199168-6 2004 Wild-type mMUTYH bound duplex oligonucleotides containing A:8-oxoG pair with a lower apparent K(d) than that of the mutants, and prevented OGG1 from excising 8-oxoG opposite adenine or the generated AP site. Oligonucleotides 30-46 mutY DNA glycosylase Mus musculus 10-16 15199168-6 2004 Wild-type mMUTYH bound duplex oligonucleotides containing A:8-oxoG pair with a lower apparent K(d) than that of the mutants, and prevented OGG1 from excising 8-oxoG opposite adenine or the generated AP site. Adenine 174-181 mutY DNA glycosylase Mus musculus 10-16 15199168-6 2004 Wild-type mMUTYH bound duplex oligonucleotides containing A:8-oxoG pair with a lower apparent K(d) than that of the mutants, and prevented OGG1 from excising 8-oxoG opposite adenine or the generated AP site. Adenine 174-181 8-oxoguanine DNA-glycosylase 1 Mus musculus 139-143