PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15175378-1 2004 In several hyperphagic models, including lactation, in which hypothalamic melanocortin signaling is reduced, a novel expression of NPY mRNA in the dorsomedial hypothalamus (DMH) has been observed, suggesting that melanocortin signaling and the induced NPY in the DMH may constitute unique neurocircuitry in mediating energy balance. 1,2-Dimethylhydrazine 173-176 neuropeptide Y Rattus norvegicus 131-134 15175378-1 2004 In several hyperphagic models, including lactation, in which hypothalamic melanocortin signaling is reduced, a novel expression of NPY mRNA in the dorsomedial hypothalamus (DMH) has been observed, suggesting that melanocortin signaling and the induced NPY in the DMH may constitute unique neurocircuitry in mediating energy balance. 1,2-Dimethylhydrazine 173-176 neuropeptide Y Rattus norvegicus 252-255 15175378-2 2004 Using lactating rats as a model, the present study first showed that in the DMH abundant alpha-MSH and agouti-related protein fibers are in close apposition to NPY-positive cells. 1,2-Dimethylhydrazine 76-79 proopiomelanocortin Rattus norvegicus 89-98 15175378-2 2004 Using lactating rats as a model, the present study first showed that in the DMH abundant alpha-MSH and agouti-related protein fibers are in close apposition to NPY-positive cells. 1,2-Dimethylhydrazine 76-79 agouti related neuropeptide Rattus norvegicus 103-125 15175378-2 2004 Using lactating rats as a model, the present study first showed that in the DMH abundant alpha-MSH and agouti-related protein fibers are in close apposition to NPY-positive cells. 1,2-Dimethylhydrazine 76-79 neuropeptide Y Rattus norvegicus 160-163 15175378-7 2004 Furthermore, MTII treatment greatly attenuated suckling-induced NPY expression in the DMH. 1,2-Dimethylhydrazine 86-89 neuropeptide Y Rattus norvegicus 64-67 15175378-9 2004 In summary, the present study demonstrated that the melanocortin system in the DMH not only plays an important role in inducing NPY expression in the DMH of lactating rats but also in regulating energy homeostasis, at least in part, by modulating appetite and energy expenditure. 1,2-Dimethylhydrazine 79-82 neuropeptide Y Rattus norvegicus 128-131