PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15167706-0	2004	Adverse drug reactions to azathioprine therapy are associated with polymorphism in the gene encoding inosine triphosphate pyrophosphatase (ITPase).	Azathioprine	26-38	inosine triphosphatase	Homo sapiens	101-137	
15167706-0	2004	Adverse drug reactions to azathioprine therapy are associated with polymorphism in the gene encoding inosine triphosphate pyrophosphatase (ITPase).	Azathioprine	26-38	inosine triphosphatase	Homo sapiens	139-145	
15167706-1	2004	Adverse drug reactions to azathioprine (AZA), the pro-drug of 6-mercaptopurine (6-MP), occur in 15% to 28% of patients and the majority are not explained by thiopurine methyltransferase (TPMT) deficiency.	Azathioprine	26-38	thiopurine S-methyltransferase	Homo sapiens	187-191	
15167706-1	2004	Adverse drug reactions to azathioprine (AZA), the pro-drug of 6-mercaptopurine (6-MP), occur in 15% to 28% of patients and the majority are not explained by thiopurine methyltransferase (TPMT) deficiency.	Azathioprine	40-43	thiopurine S-methyltransferase	Homo sapiens	187-191	
15167706-1	2004	Adverse drug reactions to azathioprine (AZA), the pro-drug of 6-mercaptopurine (6-MP), occur in 15% to 28% of patients and the majority are not explained by thiopurine methyltransferase (TPMT) deficiency.	Mercaptopurine	80-84	thiopurine S-methyltransferase	Homo sapiens	187-191	
15167706-2	2004	Inosine triphosphate pyrophosphatase (ITPase) deficiency results in the benign accumulation of the inosine nucleotide ITP.	Inosine Nucleotides	99-117	inosine triphosphatase	Homo sapiens	0-36	
15167706-2	2004	Inosine triphosphate pyrophosphatase (ITPase) deficiency results in the benign accumulation of the inosine nucleotide ITP.	Inosine Nucleotides	99-117	inosine triphosphatase	Homo sapiens	38-44	
15167706-2	2004	Inosine triphosphate pyrophosphatase (ITPase) deficiency results in the benign accumulation of the inosine nucleotide ITP.	Inosine Triphosphate	38-41	inosine triphosphatase	Homo sapiens	0-36	
15167706-3	2004	6-MP is activated through a 6-thio-IMP intermediate and, in ITPase deficient patients, potentially toxic 6-thio-ITP is predicted to accumulate.	Mercaptopurine	0-4	inosine triphosphatase	Homo sapiens	60-66	
15167706-3	2004	6-MP is activated through a 6-thio-IMP intermediate and, in ITPase deficient patients, potentially toxic 6-thio-ITP is predicted to accumulate.	6-thio-itp	105-115	inosine triphosphatase	Homo sapiens	60-66	
15167706-4	2004	The association between polymorphism in the ITPA gene and adverse drug reactions to AZA therapy was studied in patients treated for inflammatory bowel disease.	Azathioprine	84-87	inosine triphosphatase	Homo sapiens	44-48	
15167706-9	2004	Overall, heterozygous TPMT genotypes did not predict adverse drug reactions but were significantly associated with a subgroup of patients experiencing nausea and vomiting as the predominant adverse reaction to AZA therapy (OR 5.5, 95% CI 1.4-21.3, P = 0.0206).	Azathioprine	210-213	thiopurine S-methyltransferase	Homo sapiens	22-26	
15167706-10	2004	Polymorphism in the ITPA gene predicts AZA intolerance.	Azathioprine	39-42	inosine triphosphatase	Homo sapiens	20-24