PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15066441-5 2004 These water molecules in the interface perform definite "tasks" contributing to the binding energy: hydrogen bond bridges between MHC and peptide and filling empty spaces in the groove which enhance affinity without contributing to epitope specificity. Hydrogen 100-108 major histocompatibility complex, class I, C Homo sapiens 130-133