PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15063962-2 2004 This study was designed to evaluate effects of metformin therapy on serum levels of IGFBP-1 and IGF-I. Metformin 47-56 insulin like growth factor 1 Homo sapiens 96-101 15063962-10 2004 CONCLUSIONS: The present study shows that metformin therapy not only restores normal levels of insulin and testosterone, but also decreases the pool of free-bioactive IGF-I by increasing the levels of circulating IGFBP-1. Metformin 42-51 insulin like growth factor 1 Homo sapiens 167-172