PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 1482145-4 1992 Next, the corticosterone peak induced by a protective dose of IL-1 (800 ng) was simulated by administration of synthetic human adrenocorticotropic hormone 1-24 (ACTH) in normal and neutropenic mice. Corticosterone 10-24 proopiomelanocortin Homo sapiens 127-159 1482145-4 1992 Next, the corticosterone peak induced by a protective dose of IL-1 (800 ng) was simulated by administration of synthetic human adrenocorticotropic hormone 1-24 (ACTH) in normal and neutropenic mice. Corticosterone 10-24 proopiomelanocortin Homo sapiens 161-165 1482145-5 1992 Although corticosterone levels induced by pretreatment with IL-1 or ACTH were virtually identical, the ACTH-induced corticosterone peak was not associated with protection against Klebsiella pneumoniae infection in normal mice and Pseudomonas aeruginosa infection in neutropenic mice. Corticosterone 116-130 proopiomelanocortin Homo sapiens 103-107 1482145-7 1992 In addition, we found that plasma corticosterone concentrations during K. pneumoniae infection were significantly lower after pretreatment with IL-1 than after pretreatment with ACTH or vehicle, probably reflecting the better physical condition of IL-1-treated mice. Corticosterone 34-48 proopiomelanocortin Homo sapiens 178-182