PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
14724571-0	2004	All-trans retinoic acid potentiates Taxotere-induced cell death mediated by Jun N-terminal kinase in breast cancer cells.	Docetaxel	36-44	mitogen-activated protein kinase 8	Homo sapiens	76-97	
14724571-7	2004	Activation of JNK by Taxotere 0.01, 0.1 and 1.0 microM was observed at 24 h in adherent cells and increased at 48 h. Taxotere 0.001 microM-induced JNK activation started after 48 h and increased at 72 h. The timing and intensity of PARP cleavage was similar to that of JNK activation.	Docetaxel	21-29	mitogen-activated protein kinase 8	Homo sapiens	14-17	
14724571-7	2004	Activation of JNK by Taxotere 0.01, 0.1 and 1.0 microM was observed at 24 h in adherent cells and increased at 48 h. Taxotere 0.001 microM-induced JNK activation started after 48 h and increased at 72 h. The timing and intensity of PARP cleavage was similar to that of JNK activation.	Docetaxel	21-29	mitogen-activated protein kinase 8	Homo sapiens	147-150	
14724571-7	2004	Activation of JNK by Taxotere 0.01, 0.1 and 1.0 microM was observed at 24 h in adherent cells and increased at 48 h. Taxotere 0.001 microM-induced JNK activation started after 48 h and increased at 72 h. The timing and intensity of PARP cleavage was similar to that of JNK activation.	Docetaxel	21-29	mitogen-activated protein kinase 8	Homo sapiens	147-150	
14724571-7	2004	Activation of JNK by Taxotere 0.01, 0.1 and 1.0 microM was observed at 24 h in adherent cells and increased at 48 h. Taxotere 0.001 microM-induced JNK activation started after 48 h and increased at 72 h. The timing and intensity of PARP cleavage was similar to that of JNK activation.	Docetaxel	117-125	mitogen-activated protein kinase 8	Homo sapiens	14-17	
14724571-7	2004	Activation of JNK by Taxotere 0.01, 0.1 and 1.0 microM was observed at 24 h in adherent cells and increased at 48 h. Taxotere 0.001 microM-induced JNK activation started after 48 h and increased at 72 h. The timing and intensity of PARP cleavage was similar to that of JNK activation.	Docetaxel	117-125	mitogen-activated protein kinase 8	Homo sapiens	147-150	
14724571-7	2004	Activation of JNK by Taxotere 0.01, 0.1 and 1.0 microM was observed at 24 h in adherent cells and increased at 48 h. Taxotere 0.001 microM-induced JNK activation started after 48 h and increased at 72 h. The timing and intensity of PARP cleavage was similar to that of JNK activation.	Docetaxel	117-125	mitogen-activated protein kinase 8	Homo sapiens	147-150	
14724571-8	2004	JNK activation and PARP cleavage induced by 30 nM Taxotere at 48 h were reversed by curcumin, PD169316 and SP600125, JNK inhibitors in order of progressive specificity.	Docetaxel	50-58	mitogen-activated protein kinase 8	Homo sapiens	0-3	
14724571-8	2004	JNK activation and PARP cleavage induced by 30 nM Taxotere at 48 h were reversed by curcumin, PD169316 and SP600125, JNK inhibitors in order of progressive specificity.	Docetaxel	50-58	mitogen-activated protein kinase 8	Homo sapiens	117-120	
14724571-12	2004	These data demonstrate the potentiation of Taxotere-induced cell death by ATRA pretreatment in breast and prostate cancer cells, and support a mechanism through accentuated and sustained JNK activation.	Docetaxel	43-51	mitogen-activated protein kinase 8	Homo sapiens	187-190