PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 14633691-4 2003 By using wild-type and Ikkbeta gene knockout (Ikkbeta(-/-)) mouse embryo fibroblasts, we found that IKKbeta deficiency results in prolongation of arsenic-induced JNK activation, which was not due to the decreased expression of GADD45beta or X-linked Inhibitor of Apoptosis (XIAP), as suggested previously for RelA(-/-) cells treated with tumor necrosis factor alpha. Arsenic 146-153 inhibitor of kappaB kinase beta Mus musculus 23-30 14633691-4 2003 By using wild-type and Ikkbeta gene knockout (Ikkbeta(-/-)) mouse embryo fibroblasts, we found that IKKbeta deficiency results in prolongation of arsenic-induced JNK activation, which was not due to the decreased expression of GADD45beta or X-linked Inhibitor of Apoptosis (XIAP), as suggested previously for RelA(-/-) cells treated with tumor necrosis factor alpha. Arsenic 146-153 inhibitor of kappaB kinase beta Mus musculus 46-53 14633691-4 2003 By using wild-type and Ikkbeta gene knockout (Ikkbeta(-/-)) mouse embryo fibroblasts, we found that IKKbeta deficiency results in prolongation of arsenic-induced JNK activation, which was not due to the decreased expression of GADD45beta or X-linked Inhibitor of Apoptosis (XIAP), as suggested previously for RelA(-/-) cells treated with tumor necrosis factor alpha. Arsenic 146-153 mitogen-activated protein kinase 8 Mus musculus 162-165 14633691-4 2003 By using wild-type and Ikkbeta gene knockout (Ikkbeta(-/-)) mouse embryo fibroblasts, we found that IKKbeta deficiency results in prolongation of arsenic-induced JNK activation, which was not due to the decreased expression of GADD45beta or X-linked Inhibitor of Apoptosis (XIAP), as suggested previously for RelA(-/-) cells treated with tumor necrosis factor alpha. Arsenic 146-153 growth arrest and DNA-damage-inducible 45 beta Mus musculus 227-237 14633691-4 2003 By using wild-type and Ikkbeta gene knockout (Ikkbeta(-/-)) mouse embryo fibroblasts, we found that IKKbeta deficiency results in prolongation of arsenic-induced JNK activation, which was not due to the decreased expression of GADD45beta or X-linked Inhibitor of Apoptosis (XIAP), as suggested previously for RelA(-/-) cells treated with tumor necrosis factor alpha. Arsenic 146-153 X-linked inhibitor of apoptosis Mus musculus 241-272 14633691-4 2003 By using wild-type and Ikkbeta gene knockout (Ikkbeta(-/-)) mouse embryo fibroblasts, we found that IKKbeta deficiency results in prolongation of arsenic-induced JNK activation, which was not due to the decreased expression of GADD45beta or X-linked Inhibitor of Apoptosis (XIAP), as suggested previously for RelA(-/-) cells treated with tumor necrosis factor alpha. Arsenic 146-153 X-linked inhibitor of apoptosis Mus musculus 274-278 14633691-4 2003 By using wild-type and Ikkbeta gene knockout (Ikkbeta(-/-)) mouse embryo fibroblasts, we found that IKKbeta deficiency results in prolongation of arsenic-induced JNK activation, which was not due to the decreased expression of GADD45beta or X-linked Inhibitor of Apoptosis (XIAP), as suggested previously for RelA(-/-) cells treated with tumor necrosis factor alpha. Arsenic 146-153 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 309-313 14633691-4 2003 By using wild-type and Ikkbeta gene knockout (Ikkbeta(-/-)) mouse embryo fibroblasts, we found that IKKbeta deficiency results in prolongation of arsenic-induced JNK activation, which was not due to the decreased expression of GADD45beta or X-linked Inhibitor of Apoptosis (XIAP), as suggested previously for RelA(-/-) cells treated with tumor necrosis factor alpha. Arsenic 146-153 tumor necrosis factor Mus musculus 338-365 14633691-5 2003 This enhanced JNK activation was largely associated with an oxidative stress response as indicated by elevated expression of heme oxygenase-1 and the accumulation of H(2)O(2) in Ikkbeta(-/-) cells. Hydrogen Peroxide 166-174 mitogen-activated protein kinase 8 Mus musculus 14-17 14633691-5 2003 This enhanced JNK activation was largely associated with an oxidative stress response as indicated by elevated expression of heme oxygenase-1 and the accumulation of H(2)O(2) in Ikkbeta(-/-) cells. Hydrogen Peroxide 166-174 inhibitor of kappaB kinase beta Mus musculus 178-185 14633691-7 2003 Inhibition of CYP1B1 reduced both oxidative stress and arsenic-stimulated JNK activation. Arsenic 55-62 cytochrome P450, family 1, subfamily b, polypeptide 1 Mus musculus 14-20 14633691-7 2003 Inhibition of CYP1B1 reduced both oxidative stress and arsenic-stimulated JNK activation. Arsenic 55-62 mitogen-activated protein kinase 8 Mus musculus 74-77