PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 14566825-1 2003 Breast cancer resistance protein (BCRP) is a member of ATP-binding cassette transporters that has an N-terminal ATP binding domain and a C-terminal transmembrane domain (TM). Adenosine Triphosphate 55-58 ATP binding cassette subfamily G member 2 (Junior blood group) Mus musculus 0-32 14566825-1 2003 Breast cancer resistance protein (BCRP) is a member of ATP-binding cassette transporters that has an N-terminal ATP binding domain and a C-terminal transmembrane domain (TM). Adenosine Triphosphate 55-58 ATP binding cassette subfamily G member 2 (Junior blood group) Mus musculus 34-38 14566825-2 2003 Expression of wild-type BCRP confers resistance to multiple chemotherapeutic agents such as mitoxantrone, SN-38 and topotecan, but not to doxorubicin. Mitoxantrone 92-104 ATP binding cassette subfamily G member 2 (Junior blood group) Mus musculus 24-28 14566825-2 2003 Expression of wild-type BCRP confers resistance to multiple chemotherapeutic agents such as mitoxantrone, SN-38 and topotecan, but not to doxorubicin. Irinotecan 106-111 ATP binding cassette subfamily G member 2 (Junior blood group) Mus musculus 24-28 14566825-2 2003 Expression of wild-type BCRP confers resistance to multiple chemotherapeutic agents such as mitoxantrone, SN-38 and topotecan, but not to doxorubicin. Topotecan 116-125 ATP binding cassette subfamily G member 2 (Junior blood group) Mus musculus 24-28 14566825-6 2003 Cells transfected with N557D-BCRP cDNA showed similar resistance to mitoxantrone but lower resistance to SN-38 than the wild-type BCRP-transfected cells. Mitoxantrone 68-80 ATP binding cassette subfamily G member 2 (Junior blood group) Mus musculus 29-33 14566825-6 2003 Cells transfected with N557D-BCRP cDNA showed similar resistance to mitoxantrone but lower resistance to SN-38 than the wild-type BCRP-transfected cells. Irinotecan 105-110 ATP binding cassette subfamily G member 2 (Junior blood group) Mus musculus 29-33 14566825-7 2003 Cells transfected with N557E-, H630E- or H630L-BCRP cDNA showed similar degrees of resistance to mitoxantrone and SN-38. Mitoxantrone 97-109 ATP binding cassette subfamily G member 2 (Junior blood group) Mus musculus 47-51 14566825-7 2003 Cells transfected with N557E-, H630E- or H630L-BCRP cDNA showed similar degrees of resistance to mitoxantrone and SN-38. Irinotecan 114-119 ATP binding cassette subfamily G member 2 (Junior blood group) Mus musculus 47-51 14566825-9 2003 Cells transfected with R482G- or R482S-BCRP cDNA showed less intracellular accumulation of [3H]mitoxantrone than the wild-type BCRP-transfected cells. Tritium 92-94 ATP binding cassette subfamily G member 2 (Junior blood group) Mus musculus 39-43 14566825-9 2003 Cells transfected with R482G- or R482S-BCRP cDNA showed less intracellular accumulation of [3H]mitoxantrone than the wild-type BCRP-transfected cells. Mitoxantrone 95-107 ATP binding cassette subfamily G member 2 (Junior blood group) Mus musculus 39-43 14566825-10 2003 These results suggest that E446 in TM2, R482 in TM3, N557 in TM5 and H630 in TM6 play important roles in drug recognition of BCRP. e446 27-31 tropomyosin 1, alpha Mus musculus 35-38 14566825-10 2003 These results suggest that E446 in TM2, R482 in TM3, N557 in TM5 and H630 in TM6 play important roles in drug recognition of BCRP. e446 27-31 tropomyosin 1, alpha Mus musculus 48-51 14566825-10 2003 These results suggest that E446 in TM2, R482 in TM3, N557 in TM5 and H630 in TM6 play important roles in drug recognition of BCRP. e446 27-31 ATP binding cassette subfamily G member 2 (Junior blood group) Mus musculus 125-129 14566825-10 2003 These results suggest that E446 in TM2, R482 in TM3, N557 in TM5 and H630 in TM6 play important roles in drug recognition of BCRP. 2,5-Dibromo-3-fluoropyridine 53-57 ATP binding cassette subfamily G member 2 (Junior blood group) Mus musculus 125-129