PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 1453463-9 1992 In addition, CyP A is a closed beta-barrel so that neither the immunosuppressive drug cyclosporin A (CsA) nor the proline-containing substrate can bind to the hydrophobic core of the CyP A barrel, while the hydrophobic core of most other barrels is open for ligation. Cyclosporine 86-99 peptidylprolyl isomerase A Homo sapiens 13-18 1453463-9 1992 In addition, CyP A is a closed beta-barrel so that neither the immunosuppressive drug cyclosporin A (CsA) nor the proline-containing substrate can bind to the hydrophobic core of the CyP A barrel, while the hydrophobic core of most other barrels is open for ligation. Cyclosporine 101-104 peptidylprolyl isomerase A Homo sapiens 13-18 1453463-9 1992 In addition, CyP A is a closed beta-barrel so that neither the immunosuppressive drug cyclosporin A (CsA) nor the proline-containing substrate can bind to the hydrophobic core of the CyP A barrel, while the hydrophobic core of most other barrels is open for ligation. Proline 114-121 peptidylprolyl isomerase A Homo sapiens 13-18 1453463-12 1992 A water-co-operated mechanism, where the cis<-->trans isomerization might possibly consist of (1) transition of the prolyl bond and (2) release of N or C-terminal residues of substrate from CyP, is addressed. Water 2-7 peptidylprolyl isomerase G Homo sapiens 196-199