PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
1379363-4	1992	The current work reports a detailed study of PSA glycoprotein expression as influenced by steroid hormones in a human prostatic adenocarcinoma cell line, LNCaP.	Steroids	90-106	kallikrein related peptidase 3	Homo sapiens	45-48	
1379363-5	1992	First, we have examined the steroid binding specificity of the androgen receptor in this cell line.	Steroids	28-35	androgen receptor	Homo sapiens	63-80	
1379363-6	1992	In comparison with wild-type rat androgen receptor in prostate, the receptor in LNCaP cells has altered affinity for a number of steroids or analogs such as progesterone (R5020), antiprogesterone (RU486), two antiandrogens (cyperoterone acetate and hydroxyflutamide), and an androgen metabolite (epitestosterone).	Steroids	129-137	androgen receptor	Rattus norvegicus	33-50	
1379363-6	1992	In comparison with wild-type rat androgen receptor in prostate, the receptor in LNCaP cells has altered affinity for a number of steroids or analogs such as progesterone (R5020), antiprogesterone (RU486), two antiandrogens (cyperoterone acetate and hydroxyflutamide), and an androgen metabolite (epitestosterone).	Progesterone	157-169	androgen receptor	Rattus norvegicus	33-50	
1379363-6	1992	In comparison with wild-type rat androgen receptor in prostate, the receptor in LNCaP cells has altered affinity for a number of steroids or analogs such as progesterone (R5020), antiprogesterone (RU486), two antiandrogens (cyperoterone acetate and hydroxyflutamide), and an androgen metabolite (epitestosterone).	antiprogesterone	179-195	androgen receptor	Rattus norvegicus	33-50	
1379363-10	1992	The mutation and alteration of steroid-binding specificity of the androgen receptor is also correlated with PSA glycoprotein expression affected by different ligands tested.	Steroids	31-38	androgen receptor	Homo sapiens	66-83	
1379363-10	1992	The mutation and alteration of steroid-binding specificity of the androgen receptor is also correlated with PSA glycoprotein expression affected by different ligands tested.	Steroids	31-38	kallikrein related peptidase 3	Homo sapiens	108-111	
1379363-12	1992	Moreover, PSA glycoprotein could be induced by R5020, estradiol, and epitestosterone; but neither glucocorticoids nor DES had any effect on PSA induction.	Estradiol	54-63	kallikrein related peptidase 3	Homo sapiens	10-13	
1379363-12	1992	Moreover, PSA glycoprotein could be induced by R5020, estradiol, and epitestosterone; but neither glucocorticoids nor DES had any effect on PSA induction.	Epitestosterone	69-84	kallikrein related peptidase 3	Homo sapiens	10-13	
1379363-13	1992	Interestingly, although the antiandrogen, cyperotone acetate, had the ability to induce PSA, both RU486 and hydroxyflutamide could block androgen and progesterone induction of PSA glycoprotein.	cyperotone acetate	42-60	kallikrein related peptidase 3	Homo sapiens	88-91	
1379363-13	1992	Interestingly, although the antiandrogen, cyperotone acetate, had the ability to induce PSA, both RU486 and hydroxyflutamide could block androgen and progesterone induction of PSA glycoprotein.	Mifepristone	98-103	kallikrein related peptidase 3	Homo sapiens	176-179	
1379363-13	1992	Interestingly, although the antiandrogen, cyperotone acetate, had the ability to induce PSA, both RU486 and hydroxyflutamide could block androgen and progesterone induction of PSA glycoprotein.	hydroxyflutamide	108-124	kallikrein related peptidase 3	Homo sapiens	176-179	
1379363-13	1992	Interestingly, although the antiandrogen, cyperotone acetate, had the ability to induce PSA, both RU486 and hydroxyflutamide could block androgen and progesterone induction of PSA glycoprotein.	Progesterone	150-162	kallikrein related peptidase 3	Homo sapiens	176-179	
1379363-14	1992	Therefore, we conclude that the PSA glycoprotein expression is influenced predominantly by androgens via its receptor, and the mutation of the receptor can affect the expression of this cellular gene by the steroids other than androgens.	Steroids	207-215	kallikrein related peptidase 3	Homo sapiens	32-35