PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
1379241-0	1992	Inhibition by dexamethasone of beta 3-adrenergic receptor responsiveness in 3T3-F442A adipocytes.	Dexamethasone	14-27	adrenergic receptor, beta 3	Mus musculus	31-57	
1379241-2	1992	Modulation of beta 3-adrenergic receptor (beta 3AR) expression by dexamethasone was investigated in the murine 3T3-F442A adipocytic cell line.	Dexamethasone	66-79	adrenergic receptor, beta 3	Mus musculus	14-40	
1379241-2	1992	Modulation of beta 3-adrenergic receptor (beta 3AR) expression by dexamethasone was investigated in the murine 3T3-F442A adipocytic cell line.	Dexamethasone	66-79	adrenergic receptor, beta 3	Mus musculus	42-50	
1379241-3	1992	In untreated cells, a major population of binding sites (62,000-114,000 sites/cell) of low affinity for (-)-[3H] CGP12177 and (-)-[125I]iodocyanopindolol (corresponding to the beta 3AR subtype) was present along with a minor population (6,500-8,000 sites/cell) of sites of high affinity for the radioligands (corresponding to a mixture of the beta 1 and beta 2AR subtypes).	(-)-[3h] cgp12177	104-121	adrenergic receptor, beta 3	Mus musculus	176-184	
1379241-3	1992	In untreated cells, a major population of binding sites (62,000-114,000 sites/cell) of low affinity for (-)-[3H] CGP12177 and (-)-[125I]iodocyanopindolol (corresponding to the beta 3AR subtype) was present along with a minor population (6,500-8,000 sites/cell) of sites of high affinity for the radioligands (corresponding to a mixture of the beta 1 and beta 2AR subtypes).	(-)-[3h] cgp12177	104-121	hemoglobin, beta adult major chain	Mus musculus	343-362	
1379241-3	1992	In untreated cells, a major population of binding sites (62,000-114,000 sites/cell) of low affinity for (-)-[3H] CGP12177 and (-)-[125I]iodocyanopindolol (corresponding to the beta 3AR subtype) was present along with a minor population (6,500-8,000 sites/cell) of sites of high affinity for the radioligands (corresponding to a mixture of the beta 1 and beta 2AR subtypes).	(-)-[125i]iodocyanopindolol	126-153	adrenergic receptor, beta 3	Mus musculus	176-184	
1379241-3	1992	In untreated cells, a major population of binding sites (62,000-114,000 sites/cell) of low affinity for (-)-[3H] CGP12177 and (-)-[125I]iodocyanopindolol (corresponding to the beta 3AR subtype) was present along with a minor population (6,500-8,000 sites/cell) of sites of high affinity for the radioligands (corresponding to a mixture of the beta 1 and beta 2AR subtypes).	(-)-[125i]iodocyanopindolol	126-153	hemoglobin, beta adult major chain	Mus musculus	343-362	
1379241-4	1992	Long-term exposure of the cells to 250 nM dexamethasone led to a sharp decrease in beta 3AR density (less than 5,000 sites/cell) which paralleled a diminished potency of the beta 3AR-selective agonists BRL37344 and CGP12177 to stimulate the production of intracellular cAMP.	Dexamethasone	42-55	adrenergic receptor, beta 3	Mus musculus	83-91	
1379241-4	1992	Long-term exposure of the cells to 250 nM dexamethasone led to a sharp decrease in beta 3AR density (less than 5,000 sites/cell) which paralleled a diminished potency of the beta 3AR-selective agonists BRL37344 and CGP12177 to stimulate the production of intracellular cAMP.	Dexamethasone	42-55	adrenergic receptor, beta 3	Mus musculus	174-182	
1379241-5	1992	Analysis of RNA by polymerase chain reaction and nuclear run-on assays indicated that dexamethasone inhibited the synthesis of beta 3AR mRNA, resulting in 4-8-fold decrease in the steady-state levels of this mRNA.	Dexamethasone	86-99	adrenergic receptor, beta 3	Mus musculus	127-135	
1379241-6	1992	The down-regulation of beta 3AR protein and cellular mRNA appeared to be mediated by the receptor for glucocorticoids as assessed by the antagonistic action of the anti-glucocorticoid RU38486.	Mifepristone	184-191	adrenergic receptor, beta 3	Mus musculus	23-31