PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12964033-6	2003	We demonstrated that the administration of 10-20 mg/kg GdCl3 caused apoptosis of Kupffer cells and blocked the Kupffer cell effector function, as shown by a decrease in CD68 expression and phagocytic activity.	gadolinium chloride	55-60	CD68 antigen	Mus musculus	169-173	
12964033-8	2003	Furthermore, 20 mg/kg GdCl3 decreased the levels of cNOS, PKC and NF-kappaB p65 expression by 26.6, 68 and 64%, respectively.	gadolinium chloride	22-27	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	66-75	
12964033-8	2003	Furthermore, 20 mg/kg GdCl3 decreased the levels of cNOS, PKC and NF-kappaB p65 expression by 26.6, 68 and 64%, respectively.	gadolinium chloride	22-27	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	76-79	
12964033-11	2003	However, the administration of higher doses of GdCl3 (40 mg/kg) caused both hepatotoxicity and Kupffer cell necrosis, as well as an increased release of TNF, NO, and PGE2 in the liver.	gadolinium chloride	47-52	tumor necrosis factor	Mus musculus	153-156	
12964033-13	2003	Lastly, the present study also provides evidence that shows there is a positive association between the expression of cAMP, PKC, or NF-kappaB and the levels of NO, PGE2 and TNF in the liver of Kupffer-cell-blocked mice, and suggests that Kupffer cells may play a part in mediating liver function and hepatocellular activity.	Cyclic AMP	118-122	tumor necrosis factor	Mus musculus	173-176	
12964033-13	2003	Lastly, the present study also provides evidence that shows there is a positive association between the expression of cAMP, PKC, or NF-kappaB and the levels of NO, PGE2 and TNF in the liver of Kupffer-cell-blocked mice, and suggests that Kupffer cells may play a part in mediating liver function and hepatocellular activity.	Dinoprostone	164-168	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	132-141