PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12964033-6 2003 We demonstrated that the administration of 10-20 mg/kg GdCl3 caused apoptosis of Kupffer cells and blocked the Kupffer cell effector function, as shown by a decrease in CD68 expression and phagocytic activity. gadolinium chloride 55-60 CD68 antigen Mus musculus 169-173 12964033-8 2003 Furthermore, 20 mg/kg GdCl3 decreased the levels of cNOS, PKC and NF-kappaB p65 expression by 26.6, 68 and 64%, respectively. gadolinium chloride 22-27 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 66-75 12964033-8 2003 Furthermore, 20 mg/kg GdCl3 decreased the levels of cNOS, PKC and NF-kappaB p65 expression by 26.6, 68 and 64%, respectively. gadolinium chloride 22-27 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 76-79 12964033-11 2003 However, the administration of higher doses of GdCl3 (40 mg/kg) caused both hepatotoxicity and Kupffer cell necrosis, as well as an increased release of TNF, NO, and PGE2 in the liver. gadolinium chloride 47-52 tumor necrosis factor Mus musculus 153-156 12964033-13 2003 Lastly, the present study also provides evidence that shows there is a positive association between the expression of cAMP, PKC, or NF-kappaB and the levels of NO, PGE2 and TNF in the liver of Kupffer-cell-blocked mice, and suggests that Kupffer cells may play a part in mediating liver function and hepatocellular activity. Cyclic AMP 118-122 tumor necrosis factor Mus musculus 173-176 12964033-13 2003 Lastly, the present study also provides evidence that shows there is a positive association between the expression of cAMP, PKC, or NF-kappaB and the levels of NO, PGE2 and TNF in the liver of Kupffer-cell-blocked mice, and suggests that Kupffer cells may play a part in mediating liver function and hepatocellular activity. Dinoprostone 164-168 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 132-141